转化生长因子β受体Ⅰ型及Ⅱ型在慢性鼻-鼻窦炎和鼻息肉组织中的表达

Expression of transforming growth factor beta receptorⅠandⅡ in chronic rhinosinusitis, nasal polyps and normal nasal mucosa tissues

目的:探讨转化生长因子β受体(TGFβR)Ⅰ型及Ⅱ型在慢性鼻-鼻窦炎、鼻息肉及正常下鼻甲组织中表达的差异性,以及Ⅰ、Ⅱ型受体在慢性鼻窦炎、鼻息肉发病机制中可能的作用。方法:采用免疫组织化学方法检测TGFβRⅠ、TGFβRⅡ在25例慢性鼻-鼻窦炎、21例鼻息肉、17例下鼻甲组织中的表达,并比较TGFβRⅠ、TGFβRⅡ在慢性鼻-鼻窦炎、鼻息肉、正常下鼻甲组织中表达的差异。结果:TGFβRⅠ、TGFβRⅡ表达的平均灰度值在正常下鼻甲黏膜分别为175.78±7.06、165.00±1.79;在慢性鼻-鼻窦炎组织中分别为147.33±8.15、147.77±4.62;而在鼻息肉组织中分别为125.91±11.26、129.82±1.46。慢性鼻-鼻窦炎及鼻息肉组织中TGFβRⅠ、TGFβRⅡ的表达均比正常下鼻甲黏膜中的表达高,均差异有统计学意义(均P<0.01);且TGFβRⅠ、TGFβRⅡ在鼻息肉组织中的表达比在慢性鼻-鼻窦炎病变黏膜中的表达高,均差异有统计学意义(均P<0.01)。结论:TGFβRⅠ、TGFβRⅡ在慢性鼻-鼻窦炎、鼻息肉组织中具有不同的表达水平及分布特点,提示其可能在慢性鼻-鼻窦炎、鼻息肉的发生发展过程中发挥不同的作用。

To explore the expression of transforming growth factor beta receptor（TGFβR） Ⅰ , Ⅱ in the chronic rhinosinusitis, nasal polyps and normal nasal mucosa tissues. Method： The protein expression of the TGFβR I and TGFβR Ⅱ were determined by means of immunohistochemistry in chronic rhinosinusitis tissues from 25 patients, nasal polyps tissues from 21 patients and inferior turbinate mucosa tissues from 17 patients with devi ation of nasal septum. Result： ①in chronic rhinosinusitis and nasal polyps tissues, compared with controls, the expression of TGFβR I and TGFβR Ⅱ protein was increased significantly（ P〈0.01）. ②The expression of TGFβR I and TGFβRⅡ protein in nasal polyps tissues was significant increased than that in chronic rhinosinusitis tissues （ P〈0.01）. Conclusion： The different expression level and pattern of TGFβR Ⅰ and TGFβR Ⅱ in chronic rbinosinusitis and nasal polyps tissues indicates TGFβR may play a different role in the pathogenesis chronic rhinosinusitis and nasal polyps.