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K562/A02细胞株核因子-κB活性与P糖蛋白的表达 被引量：2

The study of the relationship between nuclear factor-κB(NF-κB) and P-glycoprotein(P-gp) on K562/A02 cells
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摘要 目的探讨K562/A02细胞株NF-κB活性与P-gp表达的关系。方法在K562/A02白血病耐药细胞株培养中加入NF-κB抑制剂PDTC,观察在不同浓度、不同时间下,细胞株NF-κB活性的变化与P-gp表达的关系。结果在不同浓度、不同时间的PDTC作用下,K562/A02细胞株NF-κB活性与P-gp表达呈正相关的关系,随干预浓度、时间的不断变化,二者均逐渐下降。结论NF-κB调控的白血病细胞抗凋亡机制中有MDR1的参与。 Objective To explore the relationship between nuclear factor-rB （NF-kB） and P -glycoprotein （P-gp） on K562/A02 cells. Methods NF-kB and P-gp of K562/A02 cells cultured with PDTC in different concentrations and time were detected by immunohisochemisty, and the relationship between them was analyzed. Results In K562/A02 cells, the expression of NF- kB and P-gp were positively correlated, and were concentrationdependent and the time dependent. Conclusion The mechanism of NF- kB regulating anti-apoptosis of K562/A02 cells is related with MDR1.
作者 张海涛 王漪 余敏 刘心
机构地区 西安交通大学医学院第一附属医院血液内科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2006年第4期349-351,355,共4页 Journal of Xi’an Jiaotong University（Medical Sciences）
关键词 K562/A02细胞株 核因子-KB P糖蛋白 K562/A02 nuclear factor - kB P- glycoprotein
分类号 R733.7 [医药卫生—肿瘤]
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  • 1李琦,于颖彦,朱正纲,刘炳亚,纪玉宝,张奕,程琳玲,林言箴.核转录因子-κB组成性激活对胃癌细胞增殖的影响及其机制[J].中华实验外科杂志,2004,21(8):957-960. 被引量：12
  • 2Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequence [ J ]. Cell, 1986,46 ( 5 ) : 705-716.
  • 3Baldwin AS Jr. Series introduction: the transcription factor NF-kappaB and human disease [J]. J Clin Invest, 2001,107( 1 ) :3-6.
  • 4Biswas DK, Shi Q, Baily S, et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis [J]. Proc Natl Acad Sci U S A, 2004,101 (27):10137-10142.
  • 5Sung MH, Simon R. In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics [ J]. Mol Pharmacol,2004 ,66( 1 ) :70-75.
  • 6Olsen LS, Hjarnaa PJ, Latini S, et al. Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity [ J]. lnt J Cancer, 2004,111 (2) : 198-205.
  • 7Kim SH, Song SH, Kim SG, et al. Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NFkappaB as a possible target [ J ]. J Cancer Res Clin Oncol , 2004,130(9) :551-560.
  • 8Sliva D. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy [ J ]. Curr Cancer Drug Targets,2004,4(4) :327-336.
  • 9Lauzurica P, Martinez MS, Marazuela M, et al. Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha [ J ]. Eur J Immunol, 1999,29 ( 6 ) : 1890-1900.
  • 10Golstein P. Controlling cell death [ J ]. Science, 1997,275(5303) :1081-1082.

共引文献28

同被引文献18

  • 1张翠娟,周庚寅,李丽,马丽丽,高鹏,李红.葡萄籽多酚对人乳腺癌细胞MCF-7/ADR在裸鼠体内的多药耐药逆转作用[J].中华外科杂志,2004,42(13):795-798. 被引量：8
  • 2李琦,于颖彦,朱正纲,刘炳亚,纪玉宝,张轶,陈雪华,林言箴.核转录因子κB抑制剂PDTC对胃癌细胞株增殖和凋亡相关蛋白caspase-3表达影响的实验研究[J].中国癌症杂志,2005,15(1):5-8. 被引量：11
  • 3刘娟妮,高瀛岱,王金宏,邵晓枫,范冬梅,纪庆,熊冬生,杨纯正.去除Etag标记的抗CD3/抗Pgp微型双功能抗体原核表达载体的构建及表达[J].细胞与分子免疫学杂志,2007,23(10):946-949. 被引量：1
  • 4Steven H, Elias C, Nancy LH, et al. WHO Classification of tumors. Pathology and genetics of tumors of haematopoietic and lymphoid tissues [ M ]. Lyon : IARC Press,2008:233.
  • 5Amytage JO, Weisenburger DD. New approach to classifying non-Hodgkins lymphoma:clinical features of the major his- tologic subtypes. Non-Hodgkins lymphoma Classification Project [J]. J Cli Oncol, 1998,16 (8) :2780.
  • 6Moiler MB, Kania PW, Ino Y, et al. Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma:prognos- tic significance of E2F-1 and pl6INK4A [ J ]. Leukemia, 2000,14(5) :898.
  • 7Espinosa I, Briones J, Bordes R, et al. Activation of the NF- KB signalling pathway in diffuse large B-cell lymphoma: clinical implications [ J 1. Histopathology ,2008,53 (4) :441.
  • 8Masahiko Ohsawa, Yoshihiro Ikura, Hiroko Fukushima, et a- 1. Immunohistochemical Expression of Muhidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lympho- ma[J]. Oncology,2005,68(4-6) :422.
  • 9Rovesdi I, Reielel R, Novins JR. Identification of a cellular transcription factor involved in E1A transactivation [ J ]. Cell, 1986,45 (2) :219.
  • 10Suh DS, Yoon MS, Choi KU, et al. Significance of E2F-1 overexpression in epithelial ovarian cancer[ J]. Int J Gyne-col Cancer, 2008,18 (3) :492.

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西安交通大学学报（医学版）
2006年 第4期

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