Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran:A case-control study

瞄准：为丙肝感染的传播评估可能的风险因素并且与丙肝感染在病人之中分析流行病学、临床的模式的特征。方法：在一个五年的时期期间，代表性的研究在指的 HCV 积极个人之中被进行阿瓦十 JundiShapour 大学医院(AJSUH ) 和到 2003 年 9 月 1 日的从 1999 年 9 月 1 日的肝炎诊所。控制组由指的第一次供血者组成了地区性的输血组织。连接酶的免疫吸着剂试金和 recombinant 免疫污点试金反肝炎 C 病毒(HCV ) 测试为二个组被执行。积极浆液标本为 HCV RNA 是用聚合酶链反应(PCR ) 的 retest 编辑。风险因素用一张问询表被评估。在感染的题目之中的报导风险因素(“ HCV 积极”) 与从来没暴露的题目的那些相比(“ HCV 否定”) 到 HCV。结果：514 个题目的一个总数为 HCV， 254 是 HCV 积极的被学习， 260 个 HCV 否定的施主包括了控制组。病人的吝啬的年龄是 28.4 (Std 15.22 ) 年。HCV 积极的题目是更可能的具有男性(63% 对 37%) 。输送 132 (52%) ，非静脉内(n-i.v.) 药滥用和 i.v 药滥用 37 (14.5%) ，血液透析 25 (10%) ，在战争和婚外的性欲活动(2.4%) 收到创伤，(3.6%) 纹身被发现是是 HCV 积极的独立风险因素。没有明显的风险因素能在 29 被表明(11.2%) 积极案例。结论：我们输送和 i.v 药滥用和血液透析的历史是重要的数据 indicate 在我们的区域和血屏蔽的那更小心的 pretransfusion 为 HCV 感染冒因素的风险因为 anti-HCV 必须在我们的血库被介绍。在某些生活方式模式的改进，和在这个区域的习俗可能是必要的阻止感染的传播。

AIM：To evaluate possible risk factors for the spread of hepatitis C infection and to analyze the characteristics of the epidemiological and clinical patterns among the patients with hepatitis C infection. METHODS： During a five-year period a cross-sectional study was conducted among HCV positive individuals referred to the Ahwaz JundiShapour University Hospitals （AJSUH） and Hepatitis Clinic from 1 Sept 1999 to 1 Sept 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion organization. Enzyme-linked immunosorbent assay and recombinant immunoblot assay anti-hepatitis C virus （HCV） tests were performed for two groups. Positive serum specimens were retested using polymerase chain reaction （PCR） for HCV RNA. Risk factors were evaluated using a questionnaire. Reported risk factors among infected subjects （＂HCV-positive＂） were compared to those of subjects never exposed （＂HCV-negative＂） to HCV. RESULTS： A total of 514 subjects were studied for HCV, of which 254 were HCV-positive and 260 HCV- negative donors comprised the control group. Mean age of the patients was 28.4 （Std 15.22） years. HCV-positive subjects were more likely to be of male gender （63% versus 37%）. Transfusion 132 （52%）, non-intravenous （n-iv） drug abuse and iv drug abuse 37 （14.5%）, haemodialysis 25 （10%）, receiving wounds at war and extramarital sexual activities （2.4%）, tattooing （3.6%） were found to be independent risk factors of being HCV-positive. No apparent risk factors could be demonstrated in 29 （11.2%） of the positive cases. CONCLUSION： Our data indicate that a history of transfusion and iv drug abuse and haemodialysis are important risk factors for HCV infection in our area and that more careful pretransfusion screening of blood for anti- HCV must be introduced in our blood banks. Improvements in certain lifestyle patterns, and customs in this area may be essential to prevent transmission of the infection.