Influence of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C

瞄准：与长期的丙肝(CHC ) 在病人在肝的纤维变性，浆液铁索引，和肝的铁店之中评估协会。方法：32 个 CHC 病人在我们的学习被包括。纤维变性和发炎活动的组织学的度根据 Metavir 系统被估计。包括含铁锡，铁和转铁蛋白浸透的浆液铁索引被测量。肝的铁免职被 Perl 的污点分级。结果：有严重肝的纤维变性的 CHC 病人(n = 16 ) 是比有温和纤维变性的 CHC 病人显著地旧的(n = 16 )(P = 0.024 ) 。浆液铁索引，增加的浆液铁店和积极的肝的铁污点不在二个组之间是显著地不同的。在里面多变量逻辑回归分析，在活体检视的年龄是严重肝的纤维变性的一个独立预言者(机会比率 = 1.312；P = 0.035 ) 。积极的肝的铁污点显著地与丙氨酸 aminotransferase (中高音) 的价值被联系(P = 0.017 ) ，含铁锡(P = 0.008 ) ，浆液铁(P = 0.019 ) 并且转铁蛋白浸透(P = 0.003 ) 。含铁听水平与中高音的价值显示出重要关联(r = 0.531；P = 0.003 ) ，铁(r = 0.467；P = 0.011 ) 并且转铁蛋白浸透(r = 0.556；P = 0.002 ) 。结论：我们的调查结果建议丙肝病毒(HCV ) 的严厉联系了肝损伤在活体检视与耐心的年龄被联系。有浆液的两个浆液铁索引和肝的铁免职表演关联长期的肝疾病索引，但是不与肝组织学的等级和舞台有关。

AIM： To evaluate the association among hepatic fibrosis, serum iron indices, and hepatic iron stores in patients with Chronic Hepatitis C （CHC）. METHODS： Thirty-two CHC patients were included in our study. The histological degree of fibrosis and inflammation activity was assessed according to the Metavir system. The serum iron indices including ferritin, iron and transferrin saturation were measured. Hepatic iron deposition was graded by Perls＇ stain. RESULTS： The CHC patients with severe hepatic fibrosis （n = 16） were significantly older than CHC patients with mild fibrosis （n = 16） （P = 0.024）. The serum iron indices, increased serum iron store and positive hepatic iron stain were not significantly different between the two groups. In multivariate logistic regression analysis, the age at biopsy was an independent predictor of severe hepatic fibrosis （Odds ratio = 1.312; P = 0.035）. The positive hepatic iron stain was significantly associated with the values of alanine aminotransferase （ALT） （P = 0.017）, ferritin （P = 0.008）, serum iron （P = 0.019） and transferrin saturation （P = 0.003）. The ferritin level showed significant correlation with the value ofALT （r = 0.531; P = 0.003）, iron （r = 0.467; P = 0.011） and transferrin saturation （r = 0.556; P = 0.002）. CONCLUSION： Our findings suggest that the severity of hepatitis C virus （HCV）-related liver injury is associated with patient age at biopsy. Both serum iron indices and hepatic iron deposition show correlation with serum indices of chronic liver disease but are not related to grade and stage of liver histology.