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A case of mucin producing liver metastases with intrabiliary extension

A case of mucin producing liver metastases with intrabiliary extension
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摘要 A 75-year-old man was admitted to our hospital with a diagnosis of liver metastases from colon cancer. He underwent right hemicolectomy for cecal cancer eight years ago, and had a metastatic liver tumor in segment 8 (S8), which was surgically resected about 4 years after the initial operation. Histopathological examination of the resected specimens from both operations revealed a well-differentiated adenocarcinoma with mucinous carcinoma. Four months after the second operation, computed tomography demonstrated a low-density lesion at the cut surface of the remnant liver. Although it was considered to be a postoperative collection of inflammatory fluid, it formed a cystic configuration and increased in size to approximately 5 cm in diameter. With a tentative diagnosis of a recurrence of metastatic cancer, partial hepatectomy of S8 was performed. Histological examination of the resected specimens also revealed mucinous adenocarci- noma, which had invaded into the biliary ducts, replacing and extending along its epithelium. Immunohistochemi-cally, the tumor cells were positive for cytokeratin (CK) 20, but negative for CK7. Therefore, the tumor was diagnosed as a metastatic adenocarcinoma from colonic cancer. Liver metastases of colorectal adenocarcinoma sometimes invade the Glisson's triad and grow along the biliary ducts. 一个 75 岁的人从结肠癌与肝转移的诊断进入我们的医院。他八年以前为盲肠的癌症经历了正确的半结肠切除术,并且在片断 8 有一个变形的肝肿瘤(S8 ) ,它是通过手术 resected 在起始的操作以后的大约 4 年。从两操作的 resected 标本的组织病理学说的检查与 mucinous 揭示了区分得好的腺癌。在第二操作以后的四个月,计算断层摄影术在残余肝的切割表面表明了低密度的损害。尽管是煽动性的液体的一个手术后的集合被认为,它形成了一种膀胱的配置并且在直径在尺寸增加了到约 5 厘米。与变形癌症的复发的临时诊断, S8 的部分肝切除术被执行。resected 标本的组织学的检查也揭示了粘蛋白的腺癌,它入侵了进胆管,沿着它的上皮代替并且延长。Immunohistochemically,肿瘤房间为 cytokeratin (CK ) 是积极的 20,但是为 CK7 否定。因此,肿瘤从结肠的癌症作为变形腺癌被诊断。颜色的肝转移表面的腺癌有时入侵 Glisson 的三个一组并且沿着胆管成长。
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第30期4918-4921,共4页 世界胃肠病学杂志(英文版)
关键词 Liver metastases MUCIN Intrabiliary extension Cytokeratin 7 Cytokeratin 20 粘液素 肝疾病 治疗 临床
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