川芎嗪关节腔内注射对膝骨关节炎的治疗作用

Therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis

目的:探讨川芎嗪关节腔内注射对膝骨关节炎的治疗作用。方法:71例膝骨关节炎患者随机分为两组,分别予盐酸川芎嗪注射液或透明质酸钠注射液膝关节腔内注射,每周1次,连续5周。随访3月。参照Lequesne骨关节炎严重性和活动性评估法制定观察表,分别对两组患者治疗前后Lequesne评分及疗效进行比较。结果:透明质酸钠组在治疗1周后Lequesne评分较治疗前有明显降低(P<0.01),川芎嗪组在治疗3周后Lequesne评分明显降低(P<0.01)。治疗5周后,川芎嗪组总有效率为82.1%,透明质酸钠组总有效率为87.2%,两组疗效差异无统计学意义(P>0.05)。两组在治疗过程中均未见明显的不良反应。结论:川芎嗪关节腔内注射对膝骨关节炎具有治疗作用,且无明显不良反应,但起效较慢。

Objective To evaluate the trazine on knee osteoarthritis （ OA ）. Methods therapeutic effects of intraarticular injection of ligus- Seventy-one cases of knee osteoarthritis （82 knees） were randomly divided into ligustrazine （LI） group and sodium hyaluronate （SH） group. The patients were intraarticularly injected ligustrazine or sodium hyaluronate once a week for 5 consecutive weeks, and were followed-up for 3 months. Lequesne＇ s protocol for the evaluation of OA severity and activity was used. The therapeutic effects and changes of Lequesne＇ s index were observed after the treatment. Results There was significant decrease in Lequesne＇ s index in SH group after the treatment （ P 〈 0.01 ）, but not in LI group （ P 〉 0.05 ）. Three weeks later, there was significant decrease in Lequesne＇s index in both groups after the treatment （ P 〈 0.01 ） , with no significant difference between SH and LI group （ P 〉 0.05 ）. After the 5-week treatment, the efficacy rate of the LI group was 82. 1% , and that of the SH group was 87.2 %. No serious toxic or side effect was observed during the treatment and the follow-up. Conclusion Intraarticular injection of ligustrazine has a therapeutic effect on knee OA. No adverse effect is observed, but it needs long time to take effect.