陕西汉族人p53 codon 72基因多态性与子宫颈鳞癌易患性的关系:病例对照研究

Relationship between p53 codon 72 polymorphism and liability of squamous cervical cancer in Han population of Shaanxi province: Case-control study

目的：探讨p5372密码基因多态性与子宫颈鳞癌易患性的关系．方法：在陕西地区汉族妇女中，对子宫颈鳞癌患者33例，健康对照51例进行病例对照研究，用聚合酶链反应法检测p53codon72多态性．结果：p53codon72Arg纯合子、pro纯合子、Arg／pro杂合子在病例组分别是33％，15％，52％；在对照组分别是22％，18％，61％．p53codon72Arg／Arg基因型与Pro／Pro和Arg／Pro两种基因型相比A值=1．80，95％CI=0．37—8．97，差异无统计意义（P〉0．05）．结论：p53codon72Arg纯合子可能不增加陕西地区汉族人子宫颈鳞癌易患性．

AIM： To explore the relationship between genetic polymorphism of p53 codon 72 and the risk of squamous cervical cancer. METHODS： A case-control study was conducted in Han population of Shaanxi province, involving 33 women with squamous cervical carcinoma as experimental group, and 51 same ethical normal women as control group. DNA extracted from peripheral blood samples and pathologic tissues were examined by PCR with allele specific primers. RESULTS： The rates of arginine （Arg） and proline （Pro） homozygosity and Arg/Pro heterozygosity were 33%, 15% and 52% in experimental group, respectively, 22% , 18% and 61% in control group, respectively. The A of Pro/Pro or Arg/Pro genotype was 1.80 （95% CI = 0.37-8.97 ） compared with Arg/Arg genotype. The A of Pro allele compared with Arg allele was 1. 34 （ 95% CI = 0. 68-2.62 ） . Chi-square analysis showed no significant differences between the 2 groups （P 〉 0.05 ）. CONCLUSION ： Polymorphism at codon 72 of p53 gene may be not associated with an increased susceptibility to squamous cervical cancer.