精原细胞瘤术后放疗致无精子症经综合治疗致孕1例

Integrated Treatment for Azoospermia Caused by Radiotherapy after Surgical Treatment of Spermatocytoma:a Case Report

目的:探讨精原细胞瘤手术及放疗后引起不育的治疗方法。方法:采用中药“加味水陆二仙丹”为主方,加减治疗3年。结果:“加味水陆二仙丹”为主方加减治疗第2年精液未出现精子,但患者全身症状明显改变。治疗到25个月精子密度由0增加到2.0×106/m l,且精子形态正常。卵细胞胞质内单精子注射(ICSI)使其配偶成功受孕并足月剖腹产1健康男婴。结论:中药治疗因手术及放疗精原细胞瘤患者引起的不育症是一种成功的尝试,对术前没有采取精液冷冻患者的生育问题,中药是一种可供选择的补救性治疗方法。

Objective： To investigate a therapeutic method for male infertility caused by radiotherapy after surgical treatment of spermatocytoma. Methods ： A case of azoospermia caused by radiotherapy after surgical treatment of spermatocytoma was reported and the Chinese medicine J was used as a major therapy for 3 years. Results： The patient＇s health condition was improved dramatically two years after being treated by the Chinese medicine but no sperm was found in his semen. However, three years after the treatment, his spermatozoon density was recovered from zero to 2.0 × 10^6/ml with normal morphology. His sperm was subsequently used for intracytoplasmic sperm injection, which made his spouse pregnant successfully, and an healthy male infant was born by caesarean birth. Conclusion： Chinese medicine is a successful try at treating male infertility caused by radiotherapy after surgical treatment of spermatocytoma. For those who have failed to get their sperm frozen before surgery, Chinese medicine is a choice for remediation.