摘要
中枢神经系统被认为是免疫特免器官,但其免疫特免性并不完全,组织移植后也可发生免疫排斥反应。神经干细胞(NSC)移植为治疗多种中枢神经系统疾病开辟了崭新的途径。尽管NSC具有低免疫原性,但也存在免疫排斥反应的困扰。文章就中枢神经系统的免疫学特征、中枢神经系统内免疫应答及免疫排斥反应的机制和NSC移植的免疫排斥问题进行了综述。
It is considered that the central nervous system （CNS） is an immunologically privileged organ, but its immunological privilege is not complete, and immunological rejection may also occurred after tissue transplantation. Neural stem cell （NSC） transplantation has developed a brand-new approach for the treatment of various CNS diseases. Despite the low immunogenicity of NSC, there are also troubles of immunological rejection, This article reviews the immunological characteristics of CNS, the mechanisms of immunological response and immunological rejection in CNS, as well as the problems of immunological rejection of NSC transplantation.
出处
《国际脑血管病杂志》
2006年第7期547-551,共5页
International Journal of Cerebrovascular Diseases
关键词
中枢神经系统
神经于细胞
免疫排斥
central nervous system
neural stem cell
immunological rejection
