摘要
目的探讨三苯氧胺抑制增生性瘢痕成纤维细胞的作用。方法建立兔耳增生性瘢痕动物模型,分别在瘢痕表面外涂三苯氧胺软膏(配制)和空白软膏,观察瘢痕组织、瘢痕增生指数、成纤维细胞数密度变化。结果(1)实验组比对照组增生性瘢痕体积明显减小、质地较柔软,瘢痕内毛细血管减少,成熟的成纤维细胞较多,排列比较整齐。(2)瘢痕增生指数:对照组(3.32±0.65);实验组(2.73±0.21),2组间差异有显著性(P<0.05)。(3)成纤维细胞数密度:对照组(4758±306)个/mm2,实验组(3342±3111)个/mm2。差异有显著性(P<0.05)。结论三苯氧胺软膏可抑制增生性瘢痕内成纤维细胞的增殖。
Objective To investigate the inhibitory effects of tamoxifen ointments on hypertrophic scar fibroblast.Methods The hypertrophic scar model in rabbit ears was made,then tamoxifen ointments and blank ointments were used respectively, and scar tissue, scar hyperplasia exponent and the changes of numerical density of fibroblasts were observed. Results （1） Hypertrophic scar in experimental group was much smaller than that of control group, with soft tissue, less blood capillary in scar, more lined matured fibroblast. （2） Scar hyperplasia exponent： control group 3.32 ± 0.65;experimental group 2.73 ± 0.21,there was a significant difference between the two groups （ P 〈 0. 05）. （3） Numerical density of fibroblasts： control group 4 758 ± 306; experimental group 3 342 ± 3111, there was a significant difference between two groups （ P 〈 0.05）. Conclusion Tamoxifen ointments could inhibit the increase of fibroblast in hypertrophic scar.
出处
《河北医药》
CAS
2006年第8期670-671,共2页
Hebei Medical Journal
