逐饮胶囊治疗充血性心力衰竭的实验研究

An Experimental Study on Zhuyin Capsule for the Treatment of Congestive Heart Failure

【目的】观察逐饮胶囊对充血性心力衰竭(CHF)模型大鼠的治疗作用。【方法】SD大鼠50只随机分为假手术组,模型组,中药高、低剂量组(分别以0.51、0.26 g.kg-1.d-1剂量的逐饮胶囊灌胃给药),氢氯噻嗪组(剂量为14.29 mg.kg-1.d-1);除假手术组外,其他各组均复制成CHF模型,造模后35 d开始给药,连续2 d,检测各组心功能,取各组大鼠心、肝、肺进行病理学检查。【结果】模型组动物出现心率加快,血压下降,左室舒张末压(pLVED)上升,左室等容收缩期压力上升最大速率(+dp/dtmax)下降,心室腔扩大,室壁变薄,心肌纤维化,肝淤血,肺泡水肿等,表明心衰模型复制成功。中药高剂量可显著改善上述指标(P<0.05),疗效与氢氯噻嗪相当(P>0.05)。【结论】逐饮胶囊可降低前、后负荷,改善心、肝、肺的病理学变化,其治疗CHF的作用可能与之有关。

[Objective] To investigate the therapeutic effect of Zhuyin Capsule （ZC） for the treatment of congestive heart failure （CHF）. [Methods] Fifty SD rats were randomized into five groups： A （pseudo-operation）, B （model）, C （ treated with hydrochlomthiazide 14.29 rag＂ kg^-1 d^- 1 ）, D （ treated with ZC 0.26 g. kg^-1. d^-1 ） and E （ treated with ZC 0.51 g. kg^-1. d^-1 ）. Except group A, rat models of CHF were established in other groups. Thirty-five days after the modeling, groups C, D and E were treated with corresponding drugs according to the experimental design for 2 days. Cardiac function and the pathological features of heart, liver and lung were examined. [Results] The changes in group A were as follows： heart rate became fast, blood pressure decreased, left ventricular end diastolic pressure （LVEDP） increased, the maximum rate of left ventricular pressure rise （ ＋ dp/dtmax） decreased, ventricular cavity became enlarged and the wall was thin, and there appeared myocardial fibrosis, congested liver and edema in pulmonary alveoli, indicating the success of CHF model. High-dose ZC could relieved the above changes （ P 〈 0.05） and the effect is similar to hydrochlomthiazide （ P 〉 0.05）. [ Conclusion] ZC can decrease the preload and afterload of the heart, and reduce the pathological changes of heart, liver and lung in CHF rats, which may be one of its therapeutic mechanisms.