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6-OHDA、DA和MPTP(MPP+)神经毒性作用机理 被引量：1

Neurotoxic Mechanism of 6-OHDA, Dopamine and MPTP(MPP+) in Parkionson’s Disease
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摘要 帕金森病为中枢老年退行性疾病,发病原因尚未阐明。6-OHDA、多巴胺(DA)和MPTP(MPP+)为DA能神经元相对选择性神经毒物质。研究6-OHDA、DA和MPTP(MPP+)的DA能神经毒性作用机理对于理解帕金森病的发病机理具有重要意义。利用DA能神经毒物质在体内和体外模拟帕金森病为有效防治帕金森病提供了实验依据。 Parkinson＇s disease （PD） is a neurodegenerative disorder characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta, and the etiology is unknown. It is necessary to study the selective neurotoxicity of 6- OHDA, MPTP（MPP ＋ ） and dopamine in PD , which can reproduce the histological and/or biochemical characteristics of PD in animals, such as monkey, rat and mouse. It is significant for clinical diagnosis and treatment to understand the mechanism of PD from the experimental modelsof PD.
作者 栗超跃 史锡文 郭礼和
机构地区 河南省人民医院神经外科 中国科学院上海生命科学研究院生物化学与细胞生物化学研究所
出处 《医学信息（手术学分册）》 2006年第1期69-73,共5页 Medical Information Operations Sciences Fascicule
关键词 1.6-OHDA 2.DA 3.MPTP 4.神经毒性
分类号 R742.5 [医药卫生—神经病学与精神病学] R995 [医药卫生—毒理学]
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参考文献14

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同被引文献14

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  • 3杨芳艳,蒲小平.类叶升麻苷对鱼藤酮致SH-SY5Y细胞凋亡的保护作用[J].中国药理学通报,2006,22(2):159-164. 被引量：17
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医学信息（手术学分册）
2006年 第1期

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