Synthesis of 2-Heterocyclomethyl-5-diphenylmethylene-cyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

Synthesis of 2-Heterocyclomethyl-5-diphenylmethylene-cyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

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摘要 Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTF assay in human breast cancer T47D cells. Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTF assay in human breast cancer T47D cells.

作者 Yun Hai ZHANG Lin Xiang ZHAO Zhen Jun BIAN Rui WANG Fu Yuan SUN

机构地区 School of Pharmaceutical Engineering

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第9期1181-1184,共4页 中国化学快报（英文版）

基金 supported by the National Natural Science Foundation of China(No.30171099)

关键词 CYCLOPENTANONE SYNTHESIS growth inhibition. Cyclopentanone, synthesis, growth inhibition.

分类号 R979.1 [医药卫生—药品] R914.4 [医药卫生—药物化学]

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Chinese Chemical Letters

2006年第9期

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Synthesis of 2-Heterocyclomethyl-5-diphenylmethylene-cyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

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