期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TCR基因重排在皮肤T细胞淋巴瘤中的应用 被引量：3

T Cell Receptor Gene Rearrangement in Cutaneous T-cell Lymphomas
下载PDF
导出
摘要 T细胞在成熟过程中通过T细胞表面受体基因重排,从而具有特异性识别抗原的能力,在这一过程中的任何失调都会导致疾病。皮肤T细胞淋巴瘤是由于单个淋巴细胞的恶性增殖所导致的,病变组织表现出T细胞受体基因重排克隆性。蕈样肉样肿和Sézary综合征为最常见的皮肤T细胞淋巴瘤。T细胞受体基因重排的检测在皮肤T细胞淋巴瘤的发病机制研究、分类、诊断、判断预后上有重要的作用。 T cell receptor （ TCR ） gene rearrangement is an important event in T cell ontogeny that enables T cells to specifically recognise antigens, and any dysregulation in this process may result in diseases. Cuntaneous T-cell lymphoma （ CTCL ） is caused by malignant proliferation of individual lymphocyte, and its lesional tissue shows clonality of TCR gene rearrangement. Mycosis fungoides and Sezary syndrome are the most frequent clinical types of CTCL. The detection of TCR gene rearrangement has an important role in the study of the pathogenesis, classification, diagnosis and monitoring of prognosis of CTCL.
作者 马一平 卢宪梅
机构地区 山东省皮肤病性病防治研究所
出处 《国际皮肤性病学杂志》 2006年第5期300-302,共3页 International Journal of Dermatology and Venereology
关键词 淋巴瘤 T细胞 皮肤 基因重排 受体 抗原 T细胞 Lymphoma, T cell, cutaneous Gene rearrangement Receptor, T-cell
分类号 R739.5 [医药卫生—肿瘤] R733.4 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Hughes J,Weston S,Bennetts B,et al.The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue.Pathology,2001,33:222-225.
  • 2Sandberg Y,van Gastel-Mol EJ,Verhaaf B,et al.BIOMED-2 multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnostics.J Mol Diagn,2005,7:495-503.
  • 3Assaf C,Hummel M,Dippel E,et al.High detection rate of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing.Blood,2000,96:640-646.
  • 4Assaf C,Hummel M,Steinhoff M,et al.Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma:diag nostic and prognostic implications.Blood,2005,105:503-510.
  • 5Wood GS.T-cell receptor and immunoglobulin gene rearrangements in diagnosing skin disease.Arch Dermatol,2001,137:1503-1506.
  • 6Veelken H,Wood GS,Sklar J.Molecular staging of cutaneous T-cell lymphoma:evidence for systemic involvement in early disease.J Invest Dermatol,1995,104:889-894.
  • 7Hodges E,Krishna MT,Pickard C,et al.Diagnostic role of tests for T cell receptor (TCR) genes.J Clin Pathol,2003,56:1-11.
  • 8Linnemann T,Gellrich S,Lukowsky A,et al.Polyclonal expansion of T cells with the TCR V beta type of the tumour cell in lesions of cutaneous T-cell lymphoma:evidence for possible superantigen involvement.Br J Dermatol,2004,150:1013-1017.
  • 9Sra KK,Babb-Tarbox M,Aboutalebi S,et al.Molecular diagnosis of cutaneous diseases.Arch Dermatol,2005,141:225-241.
  • 10Alessi E,Coggi A,Venegoni L,et al.The usefulness of clonality for the detection of cases clinically and/or histopathologically not recognized as cutaneous T-cell lymphoma.Br J Dermatol,2005,153:368-371.

同被引文献19

  • 1夏颖哲,盛岩,陈宜瑜.福尔马林对固定标本DNA提取和扩增的影响[J].四川动物,2006,25(3):662-665. 被引量：11
  • 2van Dongen JJ, Langerak AW, Bruggemann M, et al. Design andstandardization of PCR primers and protocols for detection of clonalimmunoglobulin and T-cell receptor gene recombinations in sus-pect lymphoproliferations: report of the BIOMED-2 ConcertedAction BMfI4-CT98-3936. Leukemia, 2003, 17(12): 2257-2317.
  • 3Cozzio A, French LE. T-cell donaiity assays: how do they com-pare?. J Invest Dermatol, 2008, 128(4): 771-773.
  • 4Kandolf Sekulovic L,Cikota B,Stojadinovic O,Basanovic J,Skiljevic D,Medenica Lj,Pavlovic M,Magic Z.TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Dermatovenerol Alp Panonica Adriat . 2007
  • 5Kim ST,Jeon YS,Sim HJ,Kim SH,Kim YK,Suh KS,Park JH,Park SW.Clinicopathologic features and T-cell receptor gene rearrangement finding of mycosis fungoides Palmaris et plantaris. JamAcadDermatol . 2006
  • 6MCCARTHY K P,SLOANE J P,KABAROWSKI JHS,et al.A Simplified Method of Detection of Clonal Rearrangement ofthe T-cell Receptor-γChain Gene. Diagnostic Molecular Pathology . 1992
  • 7Ponti R,Quaglino P,Novelli M,et al.T-cell receptor r gene rearrange-ment by multiplex polymerase chain reaction/heteroduplex analysis in patients with cutaneous T-cell lymphomaand benign inflammatory disease:correlation with climical,histological and immunophenotyp-ical findings. Br J Dematol . 2005
  • 8Kohler Sabine,Jones Carol D,Warnke Roger A,et al.PCR-Heteroduplex Analysis of T-Cell Receptor γ Gene Rearrangement in Paraffin-Embedded Skin Biopsies. The American Journal of Dermatopathology . 2000
  • 9Hughes J,Weston S,Bennets B,et al.The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue. The Journal of Pathology . 2001
  • 10Diss T C,Watts M,Pan L X,et al.The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas. Journal of Clinical Pathology . 1995

引证文献3

二级引证文献1

国际皮肤性病学杂志
2006年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部