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潜伏相关转录体在单纯疱疹病毒中的作用 被引量：5

Effects of Latency-associated Transcripts During Herpes Simplex Virus Latency and Reactivation
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摘要 潜伏相关转录体是单纯疱疹病毒潜伏期间大量存在和被转录的RNA,也是目前研究单纯疱疹病毒潜伏-复发机制的热点。通过近30年的研究,对潜伏相关转录体在单纯疱疹病毒潜伏-复发中所起的作用有了更进一步的认识,但对其作用机制了解甚少。在这一未知领域,不断有新的假说提出,但其科学性有待进一步考证。为此,总结近年来对单纯疱疹病毒潜伏相关转录体作用机制的研究成果,为开展相关研究提供理论基础。 Latency-associated transcripts （ LATs ） are viral RNAs abundantly presented and transcribed during herpes simplex virus （ HSV ） latency, also the hot spot of recent researches in the mechanism of HSV latency and reactivation. Now, through near 30 years of researches, the important function of LAT has been disclosed in HSV latency and reactivation, but its mechanism is hardly clarified. In this field, hypotheses are continually coming out, but validation of those hypotheses is needed. We will review the outcomes of recent researches in the action mechanism of HSV LAT, which may provide some theoretical bases to further studies.
作者 仕瑶慧 樊建勇 杨慧兰
机构地区 广州军区广州总医院皮肤科
出处 《国际皮肤性病学杂志》 2006年第5期324-326,共3页 International Journal of Dermatology and Venereology
基金 国家自然科学基金项目(30571668)
关键词 单纯疱疹病毒属 潜伏相关转录子 Herpes simplex vires Latency-associated transcript
分类号 R373 [医药卫生—病原生物学]
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参考文献13

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  • 2Wang K,Pesnicak L,Straus SE.Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT)promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.J Virol,1997,71:7903.
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同被引文献33

  • 1张文生,朱陵群,邓瑞春,牛福玲,田蓉.红景天甙对缺氧/缺糖损伤的SH-SY5Y细胞线粒体膜电位的影响[J].中国病理生理杂志,2004,20(7):1218-1221. 被引量：17
  • 2冯波,王蓉,盛树力.神经退行性疾病研究中拟神经细胞模型:人神经母细胞瘤株SH-SY5Y的来源特性及应用[J].中国临床康复,2006,10(6):121-123. 被引量：62
  • 3Jennifer R Kent, Wen Kang, Cathie G Miller, et al. Herpes simplex virus latency-associated transcript gene function. Journal of NeuroVirology, 2003(9): 285-290.
  • 4Jin L, Carpenter D, Moerdyk Schauwecker M, et al. Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice. J Neurovirol, 2008, 14(5): 389-400.
  • 5Carpenter D, Henderson G, Hsiang C, et al. Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity. Microb Pathog, 2008, 44(2): 98-102.
  • 6Francisco J Branco, Nigel W. Herpes simplex virus type 1 latency-associated transcript expression protects trigemihal ganglion neurons from apoptosis. J Virol, 2005, 79(14): 9019-9025.
  • 7Derfuss T, Arbusow V, Strupp M, et al. The presence of lytic HSV-1 transcripts and clonally expanded T cells with a memory effector phenotype in human sensory ganglia. Ann N YAcad Sci, 2009(1164): 300-304.
  • 8Shen W, Sa E Silva M, Jaber T, et al. Two small RNAs encoded within the first 1.5 kb of the herpes simplex virus typel (HSV-1) latency-associated transcript (LAT) can inhibit productive infection and cooperate to inhibit apoptosis. J Virol, 2009, 83(18): 9131-9139.
  • 9Everett H, McFadden. Poxviruses and apoptosis: a time to die. Curt Opin Microbiol, 2002(5): 395-402.
  • 10Daly CJ, Mcgrath JC. Fluorescent ligands and protein for the study of receptors. Phamacol Ther, 2003, 100(2): 101-118.

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国际皮肤性病学杂志
2006年 第5期

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