颅内感染患儿脑脊液和血清肿瘤坏死因子检测的临床意义

Clinical significance of tumor necrosis factor-α in cerebrospinal fluid and serum in children with intracranial infection

目的:探讨肿瘤坏死因子-α(TNF-α)在小儿颅内感染中的意义。方法:采用EL ISA法分别测定20例化脓性脑膜炎(PM),32例病毒性脑炎(VE)患儿脑脊液及血清TNF-α的含量并与20例非颅内疾病的患儿进行比较。结果:PM、VE组脑脊液和血清TNF-α水平显著高于对照组(P均<0.01),而PM组又明显高于VE组(P<0.01),PM、VE组患儿脑脊液和血清中TNF-α水平呈正相关(rpm=0.131,rve=0.089,P均<0.01);恢复期PM,VE组TNF-α含量明显下降,但仍高于对照组。结论:TNF-α参与了小儿颅内感染的病理生理过程,脑脊液中TNF-α的水平可作为病脑和化脑鉴别诊断的一个参考指标。

Objective： To study significance of tumor necrosis factor-α（TNF-α） in children with intracranial infection. Methods： The serum and cerebrospinal fluid levels of TNF-α in 20 cases with purulent meningitis（PM）, 32 cases with viral encephalitis（VE） and 20 normal children were detected by ELISA. Results ;The TNF-α levels in cases with PM were higher than those of cases with VE （ P 〈 0. 01 ） , and both of them were significant higher, compared with control group （P 〈0.01） . The cerebrospinal fluid levels of TNF-α were positively correlated with the serum levels in children with intracranial infection . （rpm=0.131 , rvc=0. 089, P（0. 01） The TNF-α levels in cases with PMor VE descended in the convalescent period, but still higher than those of control group. Conclusion：TNF-α participates in the process of intracranial infection ; Detecting the cerebrospinal fluid level of TNF-α may be an objective target to distinguish purulent meningitis and viral encephalitis.