足三里穴位注射预防医院感染及对患者免疫功能的影响

Effects of injection of Huangqi Injectio into Zusanli (ST 36) on immune function in the patient of schizophrenia

目的:探讨足三里穴位注射黄芪液预防住院慢性精神分裂症患者医院感染的效果及对免疫功能的影响。方法:对30例住院慢性精神分裂症患者给予双侧足三里穴位注射黄芪液各2mL,每周3次,共8周。并检测有关免疫项目,调查医院感染的发生情况。结果:注射组医院感染、亚感染分别是4例(13·3%)、7例次(23·3%);对照组为9例(15·0%)、19例次(31·7%),两组相比,P>0·05;两组平均服药时间分别是7·77天、11·87天,P<0·01。在注射组,与前3年平均服药时间相比分别是7·77天、14·08天(P<0·01)。在免疫指标中,IgG、IgA、IgM、T细胞亚群临床意义不大;血可溶性白细胞介素-2受体(SIL-2R)测定表明:无感染组注射前后差值最大,且服药时间越长差值越小。结论:足三里穴位注射黄芪液对预防住院慢性精神分裂症患者医院感染效果肯定,SIL-2R对观察医院感染有价值。

Objective To study on effects of injection of Huangqi Injectio into Zusanli （ST 36） on the hospital infection and immune function in the patient of schizophrenia. Methods Thirty inpatients of chronic schizophrenia were treated with injection of Huangqi Injectio into bilateral Zusanli （ST 36）, 2 mL each point, thrice each week, for 8 weeks. Relative immune indexes and the hospital infection were investigated. Results The hospital infection and the sub-infection were 4 cases （13.3%）, 7 cases-times （23.3%） in the injection group; and 9 cases （15.0%）, 19 cases-times （31.7%） in the control group, respectively, with no significant difference between the two groups （P〉0.05）. The drug-administration duration was 7.77 days/case and 11.87 days/case in the two groups, respectively （P〈0.01）. In the injection group, as compared with that of last 3 years the duration was 7.77 days/case and 14.08 days/case （P〈0.01）. IgG, IgA, IgM and T-cell subgroups did not have significant changes, but there was the most different value before and after injection in SIL-2R of the no-infection group, and the longer the drug administration duration, the smaller the different values. Conclusion Injection of Huangqi Injectio into Zusanli （ST 36） has definite effect for prevention of the hospital infection in inpatients of chronic schizophrenia, and SIL-2R is a valuable index for investigation of the hospital of infection.