摘要
人们对基因的结构和功能做了大量深入细致的研究,发现超过50%以上的人类肿瘤存在p53基因的异常,p53基因与肿瘤的发生、发展以及肿瘤病人的预后关系密切。p53基因治疗,目的是纠正恶性细胞中突变的p53基因功能,在多种肿瘤的体内外试验中显示出明显疗效,本文就该方面研究进展作一综述。
出处
《江苏医药》
CAS
CSCD
北大核心
2006年第9期844-845,共2页
Jiangsu Medical Journal
参考文献15
-
1Castillo JP,Kowalik TF.Human cytomegalovirus immediate early proteins and cell growth control.Gene,2002,290:19-34.
-
2Tokino T,Nakamura Y.The role of p53-target genes in human cancer.Crit Rev Oncol Hematol,2000,33:1-6.
-
3Wolf JK,Bodurka DC,Gano JB,et al.A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum-and paclitaxel-resistant epithelial ovarian cancer.Gynecol Oncol,2004,94:442-448.
-
4Zeimet AG,Riha K,Berger J,et al.New insights into p53 regulation and gene therapy for cancer.Biochem Pharmacol,2000,60:1153.
-
5Lebedeva IV,Su ZZ,Sarkar D,et al.Restoring apoptosis as a strategy for cancer gene therapy:focus on p53 and mda-7.Semin Cancer Biol,2003,13:169-178.
-
6Choi JW,Ahn WS,Bae SM,et al.Adenoviral p53 effects and cell-specific E7 protein-protein interactions of human cervical cancer cells.Biosens Bioelectron,2005,20:2236-2243.
-
7Huh JJ,Wolf JK,Fightmaster DL,et al.Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells.Gynecol Oncol,2003,89:243-250.
-
8Wen SF,Xie L,McDonald M,et al.Development and validation of sensitive assays to quantitate gene expression after p53 gene therapy and paclitaxel chemotherapy using in vivo dosing in tumor xenograft models.Cancer Gene Ther,2000,7:1469-1480.
-
9Edelman J,Edelman J,Nemunaitis J.Adenoviral p53 gene therapy in squamous cell cancer of the head and neck region.Curr Opin Mol Ther,2003,5:611-617.
-
10Fang B,Roth JA.The role of gene therapy in combined modality treatment strategies for cancer.Curr Opin Mol Ther,2003,5:475-482.
-
1王竞,王金万.内皮抑素研究新进展[J].国外医学(肿瘤学分册),2004,31(1):15-18. 被引量:37
-
2郑小红,何小平,朱人敏.腺病毒介导的野生型p53基因治疗肿瘤研究进展[J].医学研究生学报,2007,20(1):86-89. 被引量:10
-
3刘金,蔡荣(审校),钱程(审校).肿瘤基因治疗的策略[J].国际免疫学杂志,2006,29(3):179-184. 被引量:4
-
4王占祥.细胞因子基因治疗肿瘤的研究进展[J].实用肿瘤学杂志,1997,11(3):239-240. 被引量:1
-
5马国建.肿瘤的基因疗法[J].健康博览,1995,0(6):40-40.
-
6段开文,陈希平.抗血管生成基因治疗肿瘤的研究进展[J].昆明医学院学报,2000,21(3):69-72. 被引量:1
-
7高超.内皮抑素及其基因治疗肿瘤的新进展[J].四川医学,2003,24(1):84-86. 被引量:2
-
8孟箭,郭伟.细胞因子基因治疗肿瘤的研究[J].肿瘤学杂志,2001,7(3):180-182. 被引量:1
-
9苏明慧,王大成.p53基因的研究进展[J].内蒙古医学杂志,2011,43(S7):46-49. 被引量:2
-
10陈洁,陈莉.基因治疗肿瘤的策略及进展[J].临床肿瘤学杂志,2002,7(3):232-235. 被引量:3