摘要
目的通过电针百会、大椎对脑缺血大鼠血清GSH、GSH-PX含量的影响,探讨针刺对脑缺血治疗机理。方法采用改良Longa血管内线栓脑缺血大鼠模型,随机将31只大鼠分为假手术组、正常对照组、电针穴位组与模型组,观察各组血清中GSH含量、GSH-PX活性的变化。结果电针“百会”、“大椎”两穴可使脑缺血后血清的低GSH的含量提高、低GSH-PX酶活性增高。结论电针对脑缺血导致的脂质过氧化和自由基对脑功能损伤可能有较好的保护作用。
Objective To investigate the mechanism of acupuncture treatment of cerebral ischemia by the influence of Baihui and Dazhui electroacupuncture on serum GSH and GSH-Px contents in cerebral ischemia rats. Methods A rat model of cerebral ischemia was made by Longa intravascular thread occlusion. Thirty-one rats were randomly allocated to sham operation, normal control, point electroacupuncture and model groups. Changes in serum GSH content and GaSH-Px activity were observed in each group. Results Electroacupuncture of points Baihui and Dazhui could increase low serum serum GSH content and GaSH-Px activity subsequent to cere- bral ischemia. Condusion Electroacupuncture may have a preventing effect on lipid peroxidation due to cerebral ischemia and cere- bral lesion due to free radicals.
出处
《上海针灸杂志》
2006年第9期40-41,共2页
Shanghai Journal of Acupuncture and Moxibustion
基金
国家自然科学基金项目(90209027)
关键词
电针
脑缺血
抗氧化
GSH
GSH—Px
Electroacupuncture
Cerebral ischemia
Antioxidation
GSH
GSH-Px
