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透明质酸寡糖逆转MCF-7/ADM耐药及促凋亡作用研究 被引量：1

Effects of Hyaluronate Oligomers on Drug Resistant Reverse and Apoptosis Enhancement in MCF-7/ADM Cell Line
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摘要 [目的]研究透明质酸寡糖逆转MCF-7/ADM细胞耐药的作用。[方法]MTT法研究透明质酸寡糖对MCF-7/ADM耐药逆转作用,流式细胞术测定细胞表面耐药相关蛋白P-gp、MRP的表达及凋亡调控蛋白p53、bcl-2的表达。[结果]透明质酸寡糖可提高MCF-7/ADM对化疗药的敏感性,使P-gp、MRP表达下降,p53表达增高。[结论]透明质酸寡糖可部分逆转MCF-7/ADM耐药及促进凋亡的作用。
作者 王丽萍 王宝中 司海运 赵春亭 隋振霞
机构地区 聊城市人民医院 青岛大学医学院附属医院
出处 《中国肿瘤》 CAS 2006年第9期617-619,共3页 China Cancer
关键词 透明质酸寡糖 MCF-7/ADM 逆转耐药 凋亡
分类号 R73 [医药卫生—肿瘤]
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参考文献6

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共引文献3

同被引文献32

  • 1崔向珍,王凤山,刘爱华,郭学平.透明质酸寡糖研究进展[J].中国药学杂志,2006,41(13):964-967. 被引量：3
  • 2房雪峰,郑树.透明质酸介导的细胞游走受体基因的分子生物学特性及其与肿瘤的关系[J].医学分子生物学杂志,2007,4(2):128-131. 被引量：2
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  • 10Cui X Z,Zhou S,Xu H L,et al. Reversal effects of hyaluronan oligosaccharides on adriamycin resistance of K562/A02 cells [ J]. Anti-cancer drug,2009,20 ( 9 ) : 800-806.

引证文献1

二级引证文献1

中国肿瘤
2006年 第9期

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