不同剂量左氧氟沙星治疗下呼吸道感染的成本-效果分析

Cost-effectiveness Analysis of Levofloxacin at Different Dose for Lower Respiratory Tract Infections

目的:评价左氧氟沙星不同用药剂量治疗下呼吸道感染的成本-效果,为临床制订合理用药方案提供参考。方法:将315例下呼吸道感染患者随机分为3组,分别应用左氧氟沙星900mg(A组)、600mg(B组)、300mg(C组)进行治疗,观察临床疗效,并进行成本-效果分析。结果:3组总有效率分别为87·62%、84·76%、79·05%,细菌清除率分别为94·38%、90·80%、81·32%,不良反应发生率分别为6·67%、4·76%、3·81%;治疗成本分别为1116·75、997·82、826·46元;成本-效果比分别为12·74、11·77、10·45;AB组相对于C组的增量成本-效果比分别为33·87、30·01。结论:应用600mg左氧氟沙星进行治疗是比较合理的用药方案。

OBJECTIVE：To evaluate the cost effectiveness of levofloxacin at different dosage for lower respiratory tract infections so as to guide a rational drug use in the clinic.METHODS： 315 patients with lower tract infections were randomly assigned to receive levofloxacin at different dosage： 900mg （group A）, 600mg（group B）or 300mg（group C）, clinical efficacies were observed and cost -effectiveness analysis was performed,RESULTS： The total effective rates of the 3 groups were 87.62%,84.76% and 79.05%, respectively, the germ clearance rates were 94.38%,90.80% and 81.32%, respectively, the incidences of adverse effects were 6.67%, 4.76% and 3.81%, respectively; The treatment costs of 3 groups were 1 116.75 yuan, 997.82 yuan and 826.46 yuan, respectively; The cost - effectiveness ratios were 12.74, 11.77 and 10.45, respectively; The incremental cost -effectiveness ratios of group A and B were 33.87 and 30.01 respectively as against group C.CONCLUSION： Levofloxacin at a dosage of 600mg is the optimal one for lower respiratory tract infections.