我院1999年～2005年耐甲氧西林葡萄球菌的耐药性分析

Analysis on Drug Resistance of Meticillin-Resistant Staphylococcus from 1999～2005

目的：了解我院耐甲氧西林葡萄球菌（MRS）的耐药现状，为临床合理用药提供依据。方法：将我院1999年～2005年分离的274株葡萄球菌的药敏试验结果，应用WHONET5．3软件进行统计学分析。结果：耐甲氧西林金黄色葡萄球菌（MRSA）和耐甲氧西林表皮葡萄球菌（MRSE）的检出率为48．4％和65．9％，且其检出率逐年升高，MRS的耐药率远比甲氧西林敏感葡萄球菌（MSS）高；未检出对万古霉素耐药的葡萄球菌。结论：医院应加强对MRS的检测，临床应依据药敏结果合理选用抗菌药物治疗感染。

OBJECTIVE：To investigate drug resistance status of meticillin - resistant Staphylococcus（MRS）in our hospital for providing reference for clinical rational use of drug,METHODS： The test result of drug susceptibility of 274 strains of Staphylococcus from 1999 to 2005 was analyzed by WHONETS.3.RESULTS： The isolated rate of methicillin- resistant staphylococcus aureus（MRSA）and methicillin- resistant Staphylococcus epidermidis（MRSE） is 48.4% and 65.9% respectively, there is an increasing trend of isolated rate by yearly, the resistance rates of MRS to most antibiotics are much higher than methicillin- suscepi.ibility Staphylococcus（MSS）.None of the Staphylococcus showed resistance to vancomycin.CONCLUSIONS： To strengthen the monitoring of MRS is important in hospital, the selection of antibiotics for infection treatment should be based on the reslts of susceptibility test in clinic.