贝那普利对高血压病患者血浆同型半胱氨酸水平和血管内皮功能的影响

Effects of Benazepril on Plasma Homocysteine Level and Blood Vessel Endothelial Function in Patients with Hypertension

目的:研究贝那普利对原发性高血压患者血浆同型半胱氨酸(Hcy)水平和血管内皮功能的影响。方法:77例受试者随机分为治疗组和对照组,对照组给予常规降压治疗,治疗组在此基础上加用贝那普利,观察并比较治疗前、后血浆Hcy水平、内皮依赖性血管舒张功能(FMD)、一氧化氮(NO)浓度及血管性假性血友病因子(v WF)水平等指标的变化。结果:治疗组治疗后与治疗前及对照组治疗后比较Hcy及v WF水平均降低,NO浓度升高,FMD明显升高(P<0·001或P<0·05)。结论:贝那普利降压治疗同时可降低血浆Hcy水平,改善高血压患者的血管内皮功能。

OBJECTIVE： To observe the effects of benazepril on plasma homocysteine （Hcy） level and blood vessel endothelial function in patients with essential hypertension. METHODS： A total of 77 cases were randomly divided into treatment group and control group： the control group was treated with the conventional antihypertensives, while the treatment group was treated additionally with benazepril besides antihypertensives, plasma Hcy level, brachial artery flow - mediated dilatation （FMD） function, nitrogen monoxidum （NO） level, von willber factor （vWF） level were assayed and compared before and after treatment. RESULTS： As compared with pre- treatment or the control group after treatment, the treatment group after treatment showed lower levels of Hcy and vWF, higher level of NO and significantly improved FMD（P〈0.001 or P〈0.05） . CONCLUSIONS： Benazepril, an antihypertenslve, could be used to lower plasma Hcy level and improve endothelial function in patients with essential hypertension.