疏血通注射液对原发性肾病综合征患者血浆内皮素和可溶性白介素-2受体的影响

Effects of Shuxuetong Injection on Levels of Plasma Endothelin and Soluble Interleukin-2 Receptors in Patients with Primary Nephritic Syndrome

目的:探讨疏血通注射液治疗原发性肾病综合征(PNS)患者后对其血浆内皮素(ET)及可溶性白介素-2受体(sIL-2R)水平的影响。方法:将44例PNS患者随机分为常规治疗组20例及常规治疗加疏血通注射液治疗组(干预组)24例,观察治疗前、后2组ET及sIL-2R水平变化情况。结果:治疗前患者血浆ET、sIL-2R水平均高于正常对照组(P<0·01),2组治疗后与其治疗前水平比较均显著降低(P<0·05),治疗后2组比较具有显著性差异(P<0·05)。结论:PNS患者在常规治疗基础上加用疏血通注射液能更有效地改善患者血浆ET、sIL-2R水平,从而减轻肾组织的损害。

OBJECTIVE： To study the effects of shuxuetong injection on plasma endothelin （ET） and soluble interleukin - 2 receptors（sIL- 2R） levels in patients with primary nephritic syndrome （PNS）. METHODS： A total of 44 PNS patients were enrolled： 20 were randomly assigned to receive conventional therapy, and 24 （intervention group） to receive additional shuxuetong injection besides the conventional therapy, levels of ET and sIL- 2R in both groups were assayed before and after treatment. RESULTS： Before treatment, plasma levels of ET and sIL - 2R were significantly higher in the intervention group than in the normal control group（P〈0.01）, but which were significantly lowered in both groups after treatment as against before treatment （ P 〈 0.05）, there were significant difference between 2 groups after treatment （ P 〈 0.05）. CONCLUSIONS： The conventional therapy plus shuxuetong injection can improve levels of ET and sIL - 2R more effectively in patients with PNS so as to abate the lesion of nephridial tissues.