头孢哌酮钠及其复方制剂致皮肤不良反应的药物处理方案分析

Investigation on medication for skin adverse reaction induced by cefoperazone sodium and its compound preparations

目的:根据上海市药品不良反应监测中心提供的药物不良反应(ADR)报表,分析注射用头孢哌酮钠及其复方制剂引起皮肤及其附属器ADR后的药物治疗方案。方法:对144例ADR报表进行回顾性调查研究。结果:大多数医疗机构采取单一或联合应用抗组胺药或皮质激素类药物的用药方案,治愈73例,好转69例,2例有后遗症。结论:皮肤及其附属器损害是临床上常见的ADR,出现ADR后应尽早控制症状,及时停药,对症治疗。同时应减少或避免由治疗ADR的药物再次导致的ADR,尽量使用安全性高、费用较低廉的药物。

Objective： To investigate the medication for adverse drug reaction （ADR） of skin and its accessories induced by cefoperazone sodium injection and its compound preparations according to the reports provided by the ADR monitoring center of Shanghai. Method： A retrospective study on the 144 reports was performed. Results： Drug monotherapy or combination was a dopted by most doctors, but there were different therapeutic results. Seventy three cases were cured, 69 cases were improved and 2 cases had sequelae. Conclusion： Impairment of skin and its accessories is clinically common ADR. Once it occurs, symptoms should be controlled as early as possible and the drug should be withdrawn in time. Meanwhile, the ADR which may be induced by the drug for treating ADR needs to be avoided. Thus it is recommended that safe and cheap drugs would be appropriate for chemotherapy.