OSAS与冠状动脉病变关系的临床研究

The clinical study of the relation between OSAS and coronary artery lesions

目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)与冠状动脉病变关系,以及对其干预在冠心病预防与治疗中的作用。方法对合并鼾症的临床拟诊冠心病患者行冠状动脉造影术,剔除原发性心肌病和先天性血管发育不良后的150例患者,分析他们的OSAS的构成比。入选者分为OSAS组56例和非OSAS组94例,比较两组间的冠状动脉扩张、冠状动脉血流减慢、ACS、冠状动脉病变、多支病变、严重病变、完全闭塞病变、弥漫性长病变、分叉病变、开口病变的发生情况。结果OSAS构成占37.3%。OSAS组患者冠状动脉扩张、冠状动脉血流减慢、ACS、冠状动脉病变、多支病变、严重病变、完全闭塞病变、弥漫性长病变、分叉病变、开口病变的发生情况高于非OSAS组。结论OSAS患者的冠状动脉复杂病变发生率高,提高对OSAS的认知和干预是对冠心病预防与治疗的重要途径。

Objective To investigate the relation between obstructive sleep apnea syndyome （OSAS）and the features of coronary artery lesions by coronary angiography. Methods The epidemiology features of OSAS were analysed among 150 snoring patients who had been diognosed as possible coronary heart disease after removing the primary cardiomyopathy and congenital coronary dysplasia.The 150 patients were divided into OSAS group （n=56） and non-OSAS group （n=94） and the incidence of coronary vasodilation, the coronary slow flow, ACS, coronary artery lesions, multi -artery lesions, serious coronary stenosis,chronic total occlusions,long coronary lesions,ostial stenosis and bifurcation lesions were compared. Results The incidence of OSAS was 37.3%. The incedence of coronary vasodilation, the coronary slow flow,ACS,coronary artery lesions, multi-artery lesions,serious coronary stenosis ,chronic total occlusions,long coronary lesions,ostial stenosis and bifurcation lesions in the OSAS group were more than in the non-OSAS group. Conelnsion Patients with OSAS would have serious and complex coronary artery lesions.Deepening our understanding and interference of OSAS is an important pathway of prevention and treatment of coronary heart disease.