幽门螺杆菌感染与PCNA、TGF-α、EGFR表达关系的探讨

Study on the Relationship Between Helicobacter Pylori Infection and the Expression of PCNA、TGF-α and EGFR

采用免疫组化LSAB法对幽门螺杆菌阳性和阴性胃粘膜的PCNA、TGF-α、EGFR表达进行对比分析,结果表明HP阳性胃粘膜的PCNA、TGF-α、EGFR表达显著高于HP阴性胃粘膜(P<0.05),且在不典型增生时达高峰.结果提示HP感染的胃粘膜处于高增殖状态,并能通过刺激TGF-α/EGFR过量表达从而可能引起胃癌的发生.

The expression of PCNA, TGF-α and EGFR in the growps of HP infection and without HP infection cases were observed with immunohistochemical techniques. It was shown that the expression of TGF-α, EGFR and PCNA were significantly higher in HP infection group than in that without (P<0.05) . The results suggest that the increased epithelial cell proliferation was influenced by HP infection and associated with an increased risk of adenocarcinoma. The pathogenetic mechanism may be HP infection promotes over expression of TGF-α/EGFR.