雷公藤多甙对成人隐匿性自身免疫性糖尿病患者谷氨酸脱羧酶抗体和B细胞功能的影响

Effect of Glucosidorum Tripterygll Totorum on glutamic acid decarboxylase antibody and islet в-cell function in patients with latent autoimmune diabetes of adult

目的探讨雷公藤多甙(GTT)对成人隐匿性自身免疫性糖尿病(LADA)患者谷氨酸脱羧酶抗体(GAD-Ab)和B细胞功能的影响。方法60例LADA患者随机分为GTT组和对照组,应用GTT观察3个月前后空腹C肽、GAD-Ab和胰岛素抗体(IAA)的变化。结果①GTT组患者应用GTT治疗3个月后GAD-Ab阳性率下降,转阴率为43%,与对照组比较差异有显著性(P<0.01)。②IAA治疗前后,2组组内和组间比较差异均无显著性。③GTT组患者治疗后C肽水平略有上升,组内治疗前后比较差异无显著性,而与对照组比较差异有显著性(P<0.05)。结论研究提示GTT对GAD-Ab具有免疫抑制作用,并有一定的改善B细胞功能的趋势。

Objective To investigate the effects of Glucosidorum Tripterygll Totorum （ GTT）on glutamic acid decarboxylase antibody （GAD-Ab） and islet s-cell function of latent autoimmune diabetes in adults （LADA）. Methods 60 LADA patients were divided into GTT group and control group. Fasting C-peptide, GAD-Ab and insulin aute-antibodies （ IAA） were measured before and after 3 months GTT treatment. Results ①After treatment, the negative conversion rate of GAD-Ab was 43% in GTT group. There was statistical significance between the two groups（ P 〈0.01 ）. ②IAA was not decreased in GTT group after treatment,with no statistical difference between the two groups. ③After 3 months , fasting C -peptide was slightly increased in GTT group, with significant difference between the two groups （ P 〈 0.05 ）. Conclusion GTT exerts immune inhibition and is tended to improve islet B cell function in LADA patients.