淫羊藿总苷对缺血-再灌注损伤大鼠心肌的保护作用

Protective Effects of Total Icarrin of Epimedium Against Ishemia/Reperfusion Injury in Rats

目的探讨淫羊藿总苷对缺血-再灌注损伤大鼠心肌的保护作用及其机制。方法通过结扎大鼠左冠状动脉前降支(LAD)后再灌注造成心肌缺血-再灌注损伤模型,从心肌梗死面积及血清酶学变化观察淫羊藿总苷的抗心肌缺血作用。结果淫羊藿总苷能缩小急性心肌梗死大鼠心肌梗死面积,抑制血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)的活性,提高心肌组织中超氧化物歧化酶(SOD)的活性,同时降低丙二醛(MDA)的含量。结论淫羊藿总苷对缺血-再灌注损伤大鼠心肌具有保护作用,其作用机制与抗氧化自由基作用有关。

Objective To study the effect of total icarrin of epimedium against myocardial injury induced by ischemia and reperfusion in rats. Methods Models of myocardial ischemia were prepared by ligating the left anterior descending coronary artery of rats. The anti-myocardial ischemia action of total icarrin of epimedium was assessed by determining the changes in myocardial infarct size （MIS） and serokinases. Results Total icarrin of epimedium significantly decreased MIS in rats, and the lactic dehydrogenase （LDH） and creatine phosphokinase （CK） activity in serum, improved the activity of superoxide dismutase （SOD） and decreased the malondialdehyde （MDA） contents in myocardium. Conclusion Total icarrin Of epimedium had protective effect on the acute myocardial injury induced by ischemia and reperfusion in rats. The mechanism may be related to its role against oxygen free radicals.