心脑神力口服液对小鼠的安神益智抗疲劳作用

Effects of Xinnaoshenli Liquor on Sedative Hypnosis,Intelligence-improving and Anti-fatigue in Mice

目的研究心脑神力口服液的安神、益智和抗疲劳作用。方法将昆明小鼠每次随机分为4组,心脑神力口服液3个剂量组,分别给予0.05,0.10,0.20 g.mL-1心脑神力口服液灌胃,对照组灌胃给予纯化水,4周后,分别进行小鼠跳台实验、戊巴比妥钠催眠诱导的睡眠实验、小鼠耐低氧实验以及游泳实验等。结果各给药组小鼠第1次跳台实验的潜伏时间明显短于对照组(P<0.05),第2次跳台实验则明显长于对照组(P<0.05),并且小鼠的错误次数也低于对照组(P<0.05);戊巴比妥钠催眠诱导的睡眠实验中,入睡潜伏时间药物组短于对照组(P<0.05),睡眠时间短于对照组(P<0.05);耐低氧时间和游泳时间均比正常对照组延长(P<0.05)。结论心脑神力口服液具有较好的安神、益智、抗疲劳作用。

Objective To investigate the effects of Xinnaoshenli liquor（XNSLL） on sedative hypnosis, intelligence-improving and anti-fatigue. Methods One hundred and sixty Kunming mice were randomly divided into 4 groups, 3 experimental groups with orally given drug of the dosage 0.05 g·mL^-1, 0.10 g·mL^-1, 0.20 g·mL^-1, and a control group with orally given distilled water. After 4 weeks, the mice in 4 groups underwent several tests as step-clown test, hypnosis induced by sodium pentobarbital, hypoxia tolerance, and swimming. Results The potential time of 3 experimental groups in the first step-clown test was significantly shorter than the control group （P 〈 0.05） （increase in learning ability）, and the potential time of 3 experimental groups in the second step-clown test was longer than the control group （P 〈 0.05）, and the frequency of mistakes was much less than the control group （P 〈 0.05） （increase in memory function）. In test of hypnosis induced by sodium pentobarbital, the potential time of 3 experimental groups was shorter than the control group （P 〈 0.05）, and the sleeping time was also shorter than the control group （P 〈 0.05） （effects on sedative hypnosis）. The ability of hypoxia tolerance and the time of swimming in experimental groups were longer than the control group （P 〈 0.05） （anti-fatigue effects）. Conclusion The XNSLL had a good effect on sedative hypnosis, intelligence-improving and anti-fatigue in mice.