氨氯地平与依那普利降血压及逆转左心室肥厚的疗效比较

Comparison between the Effects of Amlodipine and Enalapril on Lowering Blood Pressure and Reversing Left Ventricular Hypertrophy

目的比较研究氨氯地平与依那普利治疗原发性高血压（EH）的降血压疗效及其对左心室肥厚（LVH）的逆转作用。方法选择EH伴LVH的患者100例，随机分成治疗组和对照组各50例。治疗组用氨氯地平5～10mg·d^-1，对照组用依那普利5～10mg·d^-1，疗程2a。治疗前停用其他降血压药物2周。治疗前测血压及超声心电图（UCG），治疗后每周至少测1次血压。并于疗程结束后进行UCG检查。结果两组治疗后血压均显著降低（P〈0．01），治疗组达目标血压时间较对照组短，两组疗程结束后左心室重量指数均较治疗前降低。结论氨氯地平与依那普利降血压同时均能逆转左心室肥厚，氨氯地平降血压疗效较好，依那普利逆转左心室肥厚疗效较好。

Objective To compare the effects between amlodipine and enalapril on lowering blood pressure in patients with essential hypertension （EH） and their reverse effects on left ventricular hypertrophy （LVH）. Methods One hundred cases of EH with LVH were randomized equally into amlodipine group （A group） and enalapril group （E group）, both with a dose of 5 - 10 mg·d^-1 for 2 years. Two weeks before the treatment, other antihypertensive medicines were removed with the blood pressure measured and the ultrasonic cardiogram taken. Blood pressures were measured at least once a week after the beginning of treatment, and the ultrasonic cardiogram was taken at the end of treatment. Results Both A and E significantly reduced blood pressure （P 〈 0.01）. The time for A group to reach to target blood pressure was much shorter than that of E group, and the LVMI was improved after the treatment in two groups. Conclusion Amlodipine and Enalapril can both reduce the blood pressure and reverse the LVH.