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富血小板血浆在颌面部非血管化骨移植中的应用 被引量：7

APPLICATION OF PLATELET-RICH PLASMA IN NON-VASCULARIED BONE GRAFT OF MAXILLOFACIAL SURGERY
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摘要 目的对近年来国内外有关富血小板血浆(platelet-richplasma,PRP)促进骨形成的作用和在颌面部非血管化骨移植中的应用进行综述。方法广泛查阅相关文献,对PRP促进骨形成作用机制进行综合分析。结果PRP应用于非血管化骨移植中有促进新骨形成的作用,其机制可能与血小板本身含有各类细胞因子相关。且已有学者将其应用于临床颌面部骨缺损修复,并取得较好效果。结论PRP存在可能的促新骨形成作用,但其具体作用机制、作用持续时间以及效应与浓度的关系仍有待进一步的研究。 Objective To introduce the application of platelet-rich plasma （PRP） in non vascularised bone grafts （NVIAG） of maxillofacial surgery and its potential mechanism in recent years. Methods The latest articles were extensively retrieved, and the potential mechanism for PRP promotes the osteogenesis was discussed. Results PRP promotes osteogenesis when applied to NVBG, and the cytokine included in platelet is thought to be the ingredient for PRP＇s effect. Some scholar has already applied PRP in the restoration of maxillofacial bone defect and got good results. Conclusion PRP has the potential to promotes osteogenesis, and more studies are needed for further understanding of its mechanism.
作者 冯扬 唐休发
机构地区 四川大学华西口腔医院颌面外科
出处 《中国修复重建外科杂志》 CAS CSCD 北大核心 2006年第9期944-946,共3页 Chinese Journal of Reparative and Reconstructive Surgery
关键词 富血小板血浆 非血管化骨移植 修复 Platelet-rich plasma Non-vascularied bone graft Repair
分类号 R782 [医药卫生—口腔医学]
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参考文献27

  • 1Marx RE,Carlson ER,Eichstaedt RM,et al.Platelet-rich plasma:Growth factor enhancement for bone grafts.Oral Surg Oral Med Oral Pathol Oral Radiol Endod,1998,85(6):638-646.
  • 2Landesberg R,Roy M,Glickman RS.Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation.J Oral Maxillofac Surg,2000,58(3):297-300.
  • 3Dugrillon A,Eichler H,Kern S,et al.Autologous concentrated platelet-rich plasma (cPRP) for local application in bone regeneration.Int J Oral Maxillofac Surg,2002,31(6):615-619.
  • 4Tsay RC,Vo J,Burke A,et al.Differential growth factor retention by platelet-rich plasma composites.J Oral Maxillofac Surg,2005,63 (4):521-528.
  • 5Landesberg R,Burke A,Pinsky D,et al.Activation of platelet-rich plasma using thrombin receptor agonist peptide.J Oral Maxiallofac Surg,2005,63(4):529-535.
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  • 7Schilephake H.Bone growth factors in maxillofacial skeletal reconstruction.Int J Oral Maxillofac Surg,2002,31(5):469-484.
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二级参考文献28

  • 1Lai CF, Cheng SL. Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastlc cells. J Biol Chem, 2002, 277 (18) :15514-15522.
  • 2Duey P,Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under eontral surveillaee. Science, 2000, 289 (5484) :1501-1504.
  • 3Otto F,Thornell AP, Crompton T,et al. Cbfal, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell, 1997, 89 (15): 765-771.
  • 4Thirunavukkarasu K,Miles RR, Halladay DL, et al. Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta(TGF-beta). Mapping of the (OPG) promoter region that mediates TGF-beta effects. J Biol Chem, 2001, 276(39) :36241-36250.
  • 5Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rlch plasma: Growth factor enhancement for hone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998,85 (6) : 638-646.
  • 6Schmitz JP, Hollinger JD. The biology of platelet-rich plasma. J Oral Maxillofac Surg, 2001,59 : 1119-1121.
  • 7Pittenger MF,Mackay AM,Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science, 1999, 284(5411) : 143-147.
  • 8Petrungaro PS. The use of platelet rich plasma with growth factors (Autologous platelet gel) to enhance hard and soft tissue healing and maturation in the reconstruction of the maxillary pneumatized sinus. Clinical Update. Contemporary Periodontics Implantology, 2001, 1(9) : 1.
  • 9Kim SG, Kim WK, Park JC, et al. A comparative study of osseointegration of Avana implants in a demineralized freeze-dried bone alone or with platelet-rich plasma. J Oral Maxillofac Surg,2002, 60(9) :1018-1025.
  • 10Piche JE,Graves DT. Study of the growth factor requirements of human bone-derived cells:a comparison with human fibroblasts.Bone, 1989,10 (2) : 131-138.

共引文献55

同被引文献116

引证文献7

二级引证文献61

中国修复重建外科杂志
2006年 第9期

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