白细胞计数与代谢综合征的关系

Association of white blood cell count with metabolic syndrome

目的:探讨白细胞(WBC)计数与代谢综合征(MS)及其亚组分的关系。方法:对662例重庆地区成年人测定了血糖、血脂、胰岛素、WBC计数、超敏C反应蛋白(hsCRP)等指标,根据2005年IDF标准诊断MS。结果:有MS者WBC计数明显高于无MS者(P<0.01),且WBC计数增高与肥胖、高血压、高血糖、高甘油三酯血症等MS亚组分均有关。根据WBC计数的四分位数,将受试者分为4组,结果提示随着WBC水平增加,腰围、BMI、SBP、DBP、TG、TC、LDL-C、HomaIR、hsCRP增高(P<0.01),而HDL-C水平降低(P<0.01)。结论:WBC计数作为炎症标志物,与MS及其亚组分关系密切,WBC计数增高可能是MS发生的标志之一。

Objective： To study the association of the white blood cell （WBC） count with metabolic syndrome（MS） and its components. Methods ：The blood glucose, blood lipid-profile, insulin, WBC count and high-sensitive C-reactive protein （ hsCRP ） were assayed in 662 adults in Chongqing city. Diagnosis of MS and its components followed the IDF consensus worldwide definition of the MS. Results ： The level of the WBC count was significantly higher in subjects with MS than that without （P〈0.01）, and there was an association between increased WBC count and components of MS （i.e. obesity, high blood pressure, high blood glucose, hypertriglyceridemia ）. Patients were categorized into four groups according to WBC count quintiles ,and patients with higher WBC count had higher waist, BMI, DBP,FPG, TG, TC,LDL-C, HomalR （P〈0.01） and hsCRP, but lower HDL-C （P〈0.01）. Conclusion ：Elevated WBC count, even within the normal range, is associated with MS and its components.