超促排卵周期胚胎移植日血清孕酮/雌二醇比值对胚胎着床的影响

The clinical study of relationship between serum P/E_2 ratio on the day of embryo transfer and embryo implantation

目的:探讨超促排卵周期胚胎移植日血清孕酮/雌二醇(P/E2)比值对子宫内膜容受性的影响。方法:将96例体外受精-胚胎移植患者按胚胎移植日(ET)血清P/E2比值分为5组,对其实验室结果和临床结局进行比较。结果:5组患者的平均年龄、ET日内膜厚度、受精率、卵裂率、可移植胚胎数及移植胚胎数均无差异(P>0.05)。组1的取卵数最多,妊娠率低;组5的取卵数最少,无1例妊娠。而组3(P/E2为100￣150)获得显著高于其他组的妊娠率和单胚种植率(P<0.05)。结论:恰当的P/E2比值可提高子宫内膜的容受性,在促排卵周期测定ET日的P/E2比值对预测妊娠成功与否有参考作用。

Objective： To study the effect of serum P/E2 ratio on the day of embryo transfer in controlled ovarian hyperstimulation（COH） on implantation. Methods： 96 cases of IVF were divided into five groups according to serum P/E2 ratio on embryo transfer （ET） day, and their laboratory results and clinical outcomes were compared. Results： There were no differences on average age, endometrium thickness on ET day,fertilization rates, embryo cleavage rates, and numbers of embryos transferred among five groups （ P 〉 0.05 ） .There was the most and the least oocytes in group 1 （P/E2 〈 50） and group 5 （P/E2 〉 200）, respectively. No patient in group 5 hecame pregnant finally, while those in group 3 （P/E2100-150） got higher pregnancy rates and single embryo implantation rates than other four groups（P 〈 0.05）. Conclusion： The optimal P/E2 ratio on the day of ET can improve endometrial receptivity, It is important to monitor serum P/E2 on the day ET to predict pregnancy in COH.