4Musher DM, Groover JE, Rowand JM, et al. Antiboby to capsular polysaccharides of streptococcus pneumoniae:prevalence , persistence, and response to revaccination. Clin Infect Dis, 1993,17( 3 ) :66-73
5Murasko DM, weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing eag. Clin exp immunol, 1987,70(4) :440
6Ershler WB. Interleukin -6:a cytokine for geronto logists ,J AM Geriatr Soc,1993,41(2) :176-181
7Schols AM, Buurman WA, staal -Van den Brekel AJ, et al. Evidence for a velation between metabolic derangements and increased levels of inflamatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax, 1996,51 (6) :819-824
8Bruunsgaard H, Skinh P, Qvist J, et al. Elderly humans show prolouged in vivo in flammatory activity during pneumococcal infections. J Infect Dis, 1999,180(2) :551-554
