夏至草提取物对血瘀大鼠器官血流量和血液流变学指标的影响

Effects of the extracts from Herba Lagopsis on organs blood perfusion and hemorrheological indexes in blood stasis rats.

目的:从器官血流量和血液流变学角度,探讨夏至草提取物的活血化瘀作用。方法:用10%高分子右旋糖酐(Dextran 500)以10ml/kg经颈静脉注射,1min注完,诱导大鼠急性血瘀症模型。6min后经颈静脉给予夏至草提取物,测定器官微区血流量和血液流变学指标。结果:夏至草提取物能明显改善小肠、胃和肝脏的器官血流量,降低血粘度和红细胞聚集指数,提高红细胞变形性。结论:夏至草提取物可改善血瘀大鼠的血液流变性异常,提高器官血液灌流,具有良好的活血化瘀作用。

Objective： To explore the effects of blood-activating and stasis-eliminating of Herba Lagopsis extracts from blood perfusion and hemorrheological indexes. Methods： The acute blood stasis model was established by iv Dextran 500 （10ml/kg） within lmin. After 6min, extracts from Herba Lagopsis was given intravenously to the treatment group, normal control group and model control group. The organs blood perfusion and hemorrheological indexes were determined in all rats. Results： The extracts from Herba Lagopsis could improve the blood perfusion of intestine, stomach and liver obviously, and reduce the bleed viscosity and erythrocyte conglomeration index, increase the erythrocyte deformability index. Conclusions： The extracts from Herba Lagopsis could improve the abnormal hemorrheological property and increase the organs blood perfusion, and it plays a role in blood-activating and stasis-eliminating.