摘要
高通量筛选技术是一种能迅速加快药物研究与开发步伐的自动化科学实验法。它允许研究人员同时操作多个实验,采用现代自动化机器技术即实验室机器人技术,现在,仅用一天时间便篚够完成对十万多种不同药物的筛选。高通量药物筛选技术最初应用于药物研发领域,是通过观察药物与小分子化合物靶点的相互作用关系认识病理学机制。
High throughput screening is a system of automated scientific experimentation that is rapidly increasing the pace of drug discovery. It allows researchers to conduct several simultaneous experiments using modern robotics and specialised laboratory technology, Over a hundred thousand compounds can now be screened in a single day. The primary application of high throughput screening in drug discovery is to identify small drug-like molecules that interact with targets implicated in mechanisms of disease.