新型(E)-1-取代苯基-3-(3′-取代吲哚基)-2-丙烯酮类化合物的合成和抗炎活性研究

Synthesis and in vivo Anti-inflammatory Activity of Novel E-1-substitutedPhenyl-3-(3′-substituted indolyl)-2-propenones

设计合成了一系列新的丙烯酮化合物3a^3p,其结构经1H NMR,IR,LC/MS确证.用化合物对小鼠耳部巴豆油炎症影响的炎症模型测定化合物3a^3i的生物活性,结果表明,化合物3d,3f,3g可明显抑制巴豆油致小鼠耳部炎症.其抑制率分别为19.5%,27.6%,16.1%.

A series of novel propenyl-one compounds 3a-3p were designed and synthesized. The title compounds were characterized by ^1H NMR, IR and LC/MS. Anti-inflammatory activity of compounds 3a-3i were evaluated with a in vivo model of mice ear acute inflammation edema induced by croton oil. Compounds 3d, 3f, 3g exhibited a potent anti-inflammatory activity and their inhibition ratios were 19.5% , 27.6% and 16.1% , respectively.