铝电解车间粉尘有机提取物及其组分遗传毒性的研究

Study on Genetoxicity of the Dust Organic Extraction and its Fractions in the Shop of Aluminium Refiner Plant

采用化学分离与体外微核试验、姐妹染色单体交换（ＳＣＥ）试验的方法，研究了铝电解车间粉尘有机提取物及其５个组分的遗传毒性。结果表明，粉尘有机提取物及其有机酸、多环芳烃、极性化合物可使微核率和ＳＣＥ率显著增高，并有一定的剂量－反应关系。有机碱和脂肪烃的微核率和ＳＣＥ率无明显增高。研究结果提示，铝电解车间粉尘有机提取物及其有机酸、多环芳烃、极性化合物中含有遗传毒物。

n thio paper,genotoxicity of the dust organic extraction and its fractions from the shop of aluminium refiner plant were studied using micronucleus test and sister chromatid exchanges (SCE) in human peripheral lymphocytes.The results showed that the dust organic extraction and its polycyclic aromatic hydrocarbons,organic acids,polar compounds increased micronucleus and SCE frequency significantly with a dose effect.The micronucleus and SCE fiequency of organic alkaloids and aliphatic components hadnt increased significantly.It had been suggested that the dust organic extraction and its organic acids,polycyclic aromatic hydrocarbons,polar compounds have genetoxicity.