1Glimcher L H,Murphy K M.Lineage commitment in the immune system:the T helper lymphocyte grows up[J].Genes Dev,2000;14(14):1693-1711.
2Iezzi G,Karjalainen K,Lanzavecchia A.The duration of antigenic stimulation determines the fate of naive and effector T cells[J].Immunity,1998;8(1):89-95.
3Maldonado-Lopez R,Moser M.Dendritic cell subsets and the regulation of Th1/Th2 responses[J].Semin Immunol,2001;13(5):275-282.
4O′Garra A.Cytokines induce the development of functionally heterogeneous T helper cell subsets[J].Immunity,1998;8(3):275-283.
5Trinchieri G.Immunobiology of interleukin-12[J].Immunol Res,1998;17:269-278.
8Wu C Y,Kirman J R,Rotte M J et al.Distinct lineages of Th1 cells have differential capacities for memory cell generation in vivo[J].Nat Immunol,2002;3(9):852-858.
4Abbas AK , Murphy KM , Sher A . Functional diversity of helper T lymphocytes [J]. Nature, 1996, 383 (6 603):787 - 793.
5Wu CY, Kirman JR, Rotte MJ, et al. Distinct lineages of Th 1 cells have differential capacities for memory cell generation in vivo [J]. Nat Immunol, 2002, 3 (9): 852- 858.
6Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins [ J]. J Immunol, 1986, 136 (7): 2 348-2 357.
8Seder RA, Gazzinelli R, Sher A, et al. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming [J]. Proc Natl Acad Sci USA, 1993, 90 (21):10 188- 10 192.
9Wu C , Wang X , Gadina M , et al . IL- 1 2 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-media-ted signaling despite the presence of high affinity IL-12bindingsites[J]. J Immunol, 2000, 165 (11): 6 221-6 228.
10Hu H, Huston G, Duso D, et al. CD4 + T cell effectors can become memory cells with high efficiency and without further division [J]. Nature Immunol, 2001, 2 (8): 705 - 710.
7Mosmaun T R,Cherwinski H,Bond M W,et al.Two types of murine helper T cell clone.I.Definition according to profiles of lymphokine activities and secreted proteins[J].J Immunol,1986,136(7):2348-2357.
8Harrington L E,Hatton R D,Mangan P R,et al.Interleukin 17-producing CD4+ effector T cells develop via a liesge distinct from The T helper type 1 and lineages[J].Nat Immunol,2005,6(11):1123-1132.
9Bettelli E,Carrier Y,Gao W,et al.Reciprocal developmental pathways for The generation of pathogenic effect or TH17 and regulatory T cells[J].Nature,2006,441(7090):235-238.
10Ouyang W,Jacobson N G,Bhattacharya D,et al.The Ets transcription factor ERM is specific and induced by IL-12 Through astat4-dependent pathway[J].PNAS,1999,96:3888-3893.