摘要
研究薯蔓黄酮(FSPV)对瘤株和动物的抗肿瘤作用。采用MTT法研究FSPV对4种瘤株生长的抑制作用;以动物移植性肿瘤肉瘤S180为模型,以环磷酰胺为阳性对照,以生理盐水为阴性对照,观察FSPV对动物的抗肿瘤作用。结果表明:FSPV能显著抑制4种瘤株的生长,并呈一定的剂量浓度关系;尤其对HL-60瘤株效果最佳。FSPV对S180荷瘤小鼠有较强的抑瘤作用(p<0.05),并以中剂量(400mg/kgbw)的抑瘤率最高;结论:FSPV对4种瘤株和移植性S180肉瘤小鼠具有抗肿瘤作用。
The antitumor effects of FSPV were studied in this paper. By using MTT assay and dye exclusion method, the inhibitory effects on 4 tumor cell lines in vitro of FSPV were studied. Cyclophosphamide was the positive control and saline the negative control. S180-beadng mice were used as animal model. The changes of tumor weight in vitro were investigated when FSPV were used. Results： The growth of 4 tumor cells is inhibited by FSPV significantly in dose-dependent manner. Especially the inhibitory effect on the HL-60 is specific up to 70.95%. The antitumor effect of FSPV on the Sts0 bearing mice is significant. The inhibitory rate is highest when the dose is 400mg/kg bw. Conclusion： FSPV have the antitumor effects on the 4 tumor cell lines and S180-beadng mice.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2006年第8期248-250,共3页
Food Science
关键词
甘薯叶柄藤
黄酮
抗肿瘤作用
MTT法
sweet potato leaf, stalk and stem
flavonoids
anti-tumor effect
MTT assay
