紫外双波长分光光度法考察注射用加替沙星在替硝唑葡萄糖注射液中配伍的稳定性

Compatible stability of gatifloxacin for injection in tinidazole glucose injection by dual ultraviolet wavelength spectrophotometry

目的:考察注射用加替沙星与替硝唑葡萄糖注射液配伍的稳定性。方法:在室温(20℃),观察8h内加替沙星(2g.L-1)与替硝唑(4g.L-1)配伍液的外观、pH值及紫外光谱的变化,用紫外双波长分光光度法测定两种药物的含量。结果:两药配伍后,8h内的含量、pH值及外观均无明显变化。结论:加替沙星与替硝唑葡萄糖注射液配伍稳定。

OBJECTIVE To study the compatibility of gatifloxacin for injection in tinidazole glucose injection. METHODS At room temperature （20℃ ）for 8 hours,a dual ultraviolet spectrophotometry was designed to study on the change of content after the combination of gatifloxacin（2 g·L^-1 ） and tinidazole（4 g·L^-1 ） ,and the change of the liquid appearance and its pH were observed. RESULTS No significant change was found in 8 hours. CONCLUSION Gatifloxacin for injection can be mixed with tinidazole glucose injection.