摘要
目的:观察蒲黄总黄酮对麻醉犬心肌耗氧量的影响。方法:采用麻醉犬冠脉流量、心肌耗氧量和心肌氧摄取率等指标的变化,研究蒲黄总黄酮对缺血心肌的作用。结果:灌胃给药30min到120min的各时间点,蒲黄总黄酮可明显增加冠脉血流量,降低心肌摄氧率和心肌耗氧量,与生理盐水组比较有显著差异(P<0.01)。
OBJECTIVE To investigate the effects of Pollen Typhae flavonoids on myocardial oxygen consumption in dogs. METHODS The parameters including coronary blood flow,myocardial oxygen consumption and myocardial oxygen uptake rate in normal anaesthetic dogs were adopted to study the effects of the Pollen Typhae flavonoids on ischemic myocardium. RESULTS Pollen Typhae flavonoids significantly intoeased coronary blood flow,markedly decreased myocardial oxygen uptake rate and myocardial oxygen consumption in the periods of 30 rain to 120 min when Pollen Typhae flavonoids given to dogs. haying markedly difference with that of normal saline group （P〈0.01 ）. CONCLUSION Pollen Typhae flavonoids have protective effects on the ischemic myocardium.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第9期1089-1092,共4页
Chinese Journal of Hospital Pharmacy
关键词
蒲黄总黄嗣
肌耗氧量
冠脉血流量
心肌氧摄取率
Pollen Typhae flavonoids
myocardial oxygen consumption
coronary blood flow
myocardial oxygen uptake rate
