5种致病菌对环丙沙星、泰能的耐药性变迁

StudyonthetransferableantibioticresistanceofCiprofoxacinandtienamto5speciesofbacteria

本实验采用琼脂平板稀释法测定了１９９５年泰能（ＩＭＰ／ＣＳ）和环丙沙星（ＣＰＬＸ）对５种１２９株临床常见致病菌的最低抑菌浓度（ＭＩＣ），并与１９９２年从临床标本分离的５种２１５株致病菌的实验结果进行了对比。实验结果表明，与１９９２年相比，５种致病菌对两药的ＭＩＣ值有较大幅度增高；致病菌对两药的敏感性降低，耐药菌株增多；致病菌对两药的交叉耐药现象更明显，交叉耐药率由１９９２年２．３％增加到１９９５年的１３．２％。

heinvitroantibacterialactivitiesofCiprofloxacinandTienamagainst129strainsisolatedclinicalyin1995werestudied.TheMICswerecomparedwiththoseofthestrainsisolatedin1992.TheresultsshowedthattheMICsofthestrainsin1995weremuchhigherthanthosein1992,andthereweremoreresistantstminsin1995.ThepercentageoftransferableresistantstrainsagainstCiprofloxcinandTienamin1995(13.2%)wassignificantdifferencefromthatin1992(2.3%).