幽门螺杆菌感染与胃炎粘膜中氨基巳糖含量的关系

Gastritis with Helicobater Pylori(HP) Infection and Gastric Mucosa Hexosamine concentration

本文作者对４６例经纤维胃镜和组织病理学诊断的慢性胃炎患者，进行了粘膜的幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，ＨＰ）尿素酶试验和病理Ｇｉｅｍｓａ染色检查及粘膜中氨基巳糖的测定。发现ＨＰ阳性胃炎病人的胃粘膜中，其氨基巳糖含量较ＨＰ阴性胃炎组明显降低。分别为３０．３４±５．５６μｇ／ｍｇ湿重和５６．８６±６．９２μｇ／ｍｇ湿重。经德诺治疗ＨＰ阴转后，胃炎好转，氨基巳糖含量明显回升。揭示氨基巳糖测定对研讨ＨＰ相关性胃炎的发生、转归有重要价值。

The purpose of this study was to evalute the relation-ship between gastric mucosa hexosamine and chronic gastritis. Gastric mucosa hexosamine concentration was 30.34±5.56μg/mg wet tissue in 30 HP positive gastritis.The concentration was significantly lower in HP positive gastritis than in HP negative gastritis (n=16, 56.86±6.92μg/mg wet tissue, p<0.05). Gastric mucosa hexosamine concentration increased in 6 gastritis cases after cleanance HP with De-Nol. (fron 28.18±5.79 to 64.35±8.12μg/mg wet tissue). The improvement in gastritis and disappearance of HP after treatment with De-Nol might contribute to the increase of gastric mucosa hexosamine. The data indicated that HP exert significant action on the gastric inflammation.