脊痛宁胶囊抗炎镇痛作用的实验研究

Experimental Study on Anti-inflammatory and Analgesic Effects of Jitongning Capsule

目的研究脊痛宁胶囊的抗炎、镇痛作用。方法以巴豆油致小鼠耳肿胀模型和角叉菜胶致大鼠足肿胀模型,观察脊痛宁胶囊的急性抗炎作用;以棉球植入小鼠腹腔致肉芽肿模型,观察脊痛宁胶囊的慢性抗炎作用;以醋酸法造成小鼠疼痛模型,观察脊痛宁胶囊的镇痛作用。结果脊痛宁胶囊对巴豆油致耳肿胀和角叉菜胶致大鼠足肿胀有显著的抑制作用,可显著抑制棉球所致肉芽肿形成,减少醋酸所致小鼠扭体次数。结论脊痛宁胶囊具有显著的抗炎、镇痛作用。

Objective To study the anti-inflammatory and analgesic effects of dingtongning Capsule. Methods Models of acute inflammatory reactions of croton oil-induced mouse ear edema and earrageenan-induced rat raw swelling and chronic inflammatory reaction of cotton ball-induced mouse granuloma in abdominal cavity were performed to study the anti-inflammatory effects of dingtongning Capsule. Model of acetic acid-induced writhing in mice was used to study the analgesic effect of dingtongning Capsule. Results dingtongning Capsule significantly suppressed croton oil-induced mouse ear edema and carrageenan-induce rat paw swelling. Cotton ball-induced mouse granuloma in abdominal cavity was also markedly reduced by dingtongning Capsule. The writhing times of mice induced by acetic acid were decreased by dingtongning Capsule. Conclusion dingtongning Capsule has obvious anti-inflammatory effect on acute and chronic inflammatory reactions. The pain reactions induced by chemical stimulus was significantly relieved by dingtongning Capsule.