针刺“足三里”穴对慢性酒精性肝损伤大鼠肝细胞膜的影响

Influence of Acupuncturing“Zu san li”Point on the Liver Cell Membrane of Chronic Alcohol Liver Injury Rats

目的观察电针“足三里”穴对酒精性肝损伤大鼠模型的防治效应,探讨其对肝细胞膜的调节作用。方法60%乙醇灌胃建立酒精性肝损伤大鼠模型,观察电针“足三里”穴对大鼠肝总磷脂、总胆固醇及磷脂组分的影响。结果电针“足三里”穴可提高肝细胞磷脂酰胆碱(PC)、磷脂酰乙醇胺(PE)含量,降低肝细胞总胆固醇(Chol)、神经磷脂(SM)含量,降低膜老化指数C/P、SM/PC值。结论电针“足三里”穴对酒精性肝损伤大鼠的作用机制可能为:保护肝细胞膜,改善肝细胞膜流动性。

Objective To investigate the function and possible mechanism of acupuncturing ＂Zusanli＂ point on the liver cell membrane of rat with chronic alcohol liver injury. Methods Chronic alcoholic liver damage rat model was established by 60% ethanal intragastric infusion for 60 d. Total phosphatide, total cholesterol and phosphatide component were determined. Result Compare with the normal recovery group, acupuncture ＂Zusanli＂ point can increase the content of PC and PE, decrease the content of Chol and SM of liver cell, and reduce the membrane aging index C/P, SM /PC. Conclusion Acupuncture ＂Zusanli＂ point has the function of protecting the liver cell membranes and improving the liver cell membrane＇s fluidity of chronic alcohol liver injury rat.