钙通道阻滞剂在肾移植术后早期应用的临床研究

Study of the Effects of Calcium Channel Blockers on Renal Allografts in Early stage of Renal Transplantation.

对６０例肾移植受者应用钙通道阻滞剂（ＣＡ），以同期１７例受者作为对照。ＣＡ组及对照组ＡＴＮ发生率分别为１０．０％和１７．６％，一月内ＡＲ发生率为１１．７％和２９．４％。ＣＡ组ＳＣｒ下降速度及一月内各时相ＳＣｒ值均优于同期对照组，ｐ＜０．０１。ＣＡ组一月内ＣｓＡ剂量均低于同期对照组，但ＣｓＡ血药浓度较同期对照组高８．７～２２．５％，ｐ＜０．０５。ＣＡ使用期间未见明显毒、副作用。提示：ＣＡ对促进移植肾功恢复，提高ＣｓＡ血药浓度，降低ＣｓＡ肾毒性效果显著，使用安全。

The effects of calcium channel blockers (CA) on renal allografts in early stage of renal transplantation were investigated in 60 recipients. 17 recipients without CA intake served as control. The incidence of ATN in CA group and control was 10.0% and 17.6%, respectively; the incidence of AR within the first month after operation was 11.9% and 29.4%, respectively. The SCr was lower in CA group than that in control. The CsA blood levels were 8.7￣22.5% higher in CA than those in control,even though less CsA was used in CA. There were no obvious toxic and side effects duing the use of CA. The results suggest that CA has the effects to promote the early recovery of renal graft's function, to increase the CsA level and to reduce the nephrotoxicity of CsA.