药物洗脱支架对糖尿病血运重建中期临床结果的影响

Effect of drug eluting stents on intermediate results of revascularization in patients with diabetes mellitus

目的评价药物洗脱支架（DES）对糖尿病患者冠状动脉血运重建结果的影响。方法回顾置人DES糖尿病患者的临床、冠状动脉病变与血运重建资料，并进行临床随访。结果204例糖尿病患者接受经皮冠状动脉介入治疗（PCI）时置入了一个或以上的DES，共置入316枚支架，其中DES254枚。180例患者术后接受了平均为9．3±5（6～26）个月的临床随访（随访率88．2％）。主要不良心脏事件（包括死亡、再梗死和再次血运重建）发生率为3．9％（8／204）。18例患者平均于PCI术后6．7（5．5～10）个月接受造影复查（造影随访率8．8％），经DES处理的病变无1例出现再狭窄。结论糖尿病患者使用DES安全有效，能显著降低再狭窄率和靶病变再次血运重建率。

Objective To evaluate the effect of drug eluting stents on the intermediate results of revascularization in patients with diabetes mellitus. Methods Clinical and angiographic data were collected retrospectively;clinical follow up data was obtained in most patients. Results 204 patients with diabetes were implanted one or more sirolimus eluting stents between October 2002 and December 2004. Clinical follow-up were performed in 180 patients （ 180/204,88.2% ） ,18 patients （ 18/204,8.8% ） received angiography follow-up, during follow-up, there was no death of any cause. And restenosis was not found in the target lesions implanted with DES. The rate of main adverse cardiovascular events （ death, new-oneset myocardial infarction and repeat revascularization） were 3.9% （8/204）. Conclusion DES is safe and effi- cacious in patients with diabetes which can markedly reduce restenosis and target lesion revascularization.