糖苷合成研究(Ⅹ Ⅸ)1-乙氧甲基-5-氟脲嘧啶糖苷的合成

The synthesis and characterization of glycosides of 1-ethoxymethyl-5-fluorouracil

在相转移条件下,使2,3,4,6-四-O-乙酰基-1-溴-1-脱氧--αD-吡喃葡萄糖(1A)、2,3,4-三-O-乙酰基-1-溴-1-脱氧--αD-吡喃木糖(1B)、2,3,4-三-O-乙酰基-1-溴-1-脱氧--αD-吡喃葡萄糖醛酸甲酯(1C)与1-乙氧甲基-5-氟脲嘧啶2反应,合成了3个新的1-乙氧甲基-5-氟脲嘧啶糖苷3(A^C).3(A^C)经氨解脱乙酰基,得3个新的化合物4(A′~C′),其结构经IR1、HNMR及元素分析证实.

Three N-glycosides 3 （A - C） of 1-ethoxymethyl-5-fluorouracil were synthesized by the reaction of 2 with α-bromoacetylglycose 1（A - C） under phase transfer catalysis. The compounds 3（A - C） were treated by ammonia to obtain three new compounds 4（A＇ - C＇）. Their structures were confirmed by elementary analysis , IR , and ^1HNMR.